News tagged with metabolic stress
New factor to control oncogene-induced senescence
An article published on the journal Nature describes the major role that Pyruvate dehydrogenase (PDH) —an enzyme of cellular energy metabolism— plays in the regulation of the cellular senescence induce ...
Cancer
9 hours ago |
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Posttraumatic stress disorder associated with type 2 diabetes
The presence of posttraumatic stress disorder is significantly associated with the development of type 2 diabetes. This is the finding of scientists from the Helmholtz Zentrum München and the University Hospital Gießen ...
Psychology & Psychiatry
May 16, 2013 |
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Surprising culprits behind cell death from fat and sugar overload
Excess nutrients, such as fat and sugar, don't just pack on the pounds but can push some cells in the body over the brink. Unable to tolerate this "toxic" environment, these cells commit suicide.
Medical research
Jul 05, 2011 |
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Losing sleep? Scientists evaluate why
The issue of sleep deprivation has gone beyond the counting of sheep and into the scientific domain, as European researchers set up 'sleep labs' to study the biomedical and sociological factors keeping us ...
Health
May 03, 2013 |
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Cancer suppressor gene links metabolism with cellular aging
The tumor suppressor protein p53 is an attractive target for drug developers. But this path has so far proven difficult, as most p53 regulatory proteins operate via protein-protein interactions, which make for poor drug targets, ...
Cancer
Jan 13, 2013 |
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Scientists identify molecular process in fat cells that influences stress and longevity
As part of their ongoing research investigating the biology of aging, the greatest risk factor for type 2 diabetes and other serious diseases, scientists at Joslin Diabetes Center have identified a new factor—microRNA ...
Medical research
Sep 26, 2012 |
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Treatment target for diabetes, Wolfram syndrome
Inflammation and cell stress play important roles in the death of insulin-secreting cells and are major factors in diabetes. Cell stress also plays a role in Wolfram syndrome, a rare, genetic disorder that ...
Inflammatory disorders
Aug 07, 2012 |
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Researchers identify new target for common heart condition
Researchers have found new evidence that metabolic stress can increase the onset of atrial arrhythmias, such as atrial fibrillation (AF), a common heart condition that causes an irregular and often abnormally fast heart rate. ...
Cardiology
Jan 08, 2013 |
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Key enzyme plays roles as both friend and foe to cancer
A molecule thought to limit cell proliferation also helps cancer cells survive during initial tumor formation and when the wayward cells spread to other organs in the body, researchers at the University of ...
Medical research
Jun 14, 2012 |
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Researchers find that alcohol consumption damages brain's support cells
Alcohol consumption affects the brain in multiple ways, ranging from acute changes in behavior to permanent molecular and functional alterations. The general consensus is that in the brain, alcohol targets mainly neurons. ...
Neuroscience
Mar 18, 2013 |
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Diabetes drug could hold promise for lung cancer patients
Ever since discovering a decade ago that a gene altered in lung cancer regulated an enzyme used in therapies against diabetes, Reuben Shaw has wondered if drugs originally designed to treat metabolic diseases ...
Cancer
Jan 29, 2013 |
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Lack of sleep affects bone health and bone marrow activity
Scientists at the Medical College of Wisconsin, in a team led by Carol Everson, Ph.D., professor of neurology, cell biology, neurobiology and anatomy, have discovered abnormalities in bone and bone marrow in rats undergoing ...
Medical research
Sep 18, 2012 |
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Stem cell survival strategy key to blood and immune system health
Stem cells of the aging bone marrow recycle their own molecules to survive and keep replenishing the blood and immune systems as the body ages, researchers at UC San Francisco (UCSF) have discovered.
Medical research
Feb 14, 2013 |
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Why getting healthy can seem worse than getting sick
A new article in The Quarterly Review of Biology helps explain why the immune system often makes us worse while trying to make us well.
Immunology
Mar 20, 2012 |
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Discovery spurred by unique twist of fate
(Medical Xpress)—As people age, or as a result of poor nutrition, heart valves can become damaged by the accumulation of calcium deposits within the tissue. This calcification causes a thickening and hardening ...
Cardiology
Feb 21, 2013 |
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