Researchers reveal a chemo-resistant cancer stem cell as cancer's 'Achilles' heel'
Scientists at Mount Sinai School of Medicine have discovered a subpopulation of cells that display cancer stem cell properties and resistance to chemotherapy, and participate in tumor progression. This breakthrough could ...
Cancer
Sep 10, 2012 |
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Study identifies human melanoma stem cells
(Medical Xpress)—Cancer stem cells are defined by three abilities: differentiation, self-renewal and their ability to seed a tumor. These stem cells resist chemotherapy and many researchers posit their ...
Cancer
Aug 23, 2012 |
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Study reveals new molecular target for melanoma treatment
A laboratory study led by UNC medical oncologist Stergios Moschos, MD, demonstrates how a new targeted drug, Elesclomol, blocks oxidative phosphorylation, which appears to play essential role in melanoma that has not been ...
Cancer
Aug 17, 2012 |
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Combination therapy delivers one-two punch to skin cancer, boosting anti-tumor activity
(Medical Xpress) -- Treating metastatic melanoma by combining immunotherapy with a drug that inhibits the cancer-spreading activity of a common gene mutation significantly increased survival times in an animal model, according ...
Cancer
Aug 16, 2012 |
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Zaltrap approved for advanced colorectal cancer
(HealthDay) -- Zaltrap (ziv-afilbercept) has been approved by the U.S. Food and Drug Administration in combination with a FOLFIRI chemotherapy regimen for adults with advanced metastatic (spreading) colorectal cancer, the ...
Medications
Aug 04, 2012 |
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Anastrozole and fulvestrant combo better than single drug for metastatic breast cancer
Results of a SWOG clinical trial published August 2 in the New England Journal of Medicine show the combination of anastrozole and fulvestrant extended the median survival time of women with hormone receptor-positive metast ...
Cancer
Aug 01, 2012 |
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Drug duo turns on cancer-fighting gene in kidney, breast cancers
A potentially powerful new approach to treating two lethal metastatic cancers — triple negative breast cancer and clear cell renal cell carcinoma, the most common form of kidney cancer — has been discovered by researchers ...
Cancer
Jul 31, 2012 |
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Computational analysis identifies drugs to treat drug-resistant breast cancer
Researchers have used computational analysis to identify a new Achilles heel for the treatment of drug-resistant breast cancer. The results, which are published in Molecular Systems Biology, reveal that t ...
Medications
Jul 31, 2012 |
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Metastatic breast cancer: Bevacizumab slows progression, but has no impact on survival
The cancer drug bevacizumab (Avastin) offers only a modest benefit in delaying disease progression in patients with advanced stage breast cancer, according to a systematic review by Cochrane researchers. The researchers assessed ...
Cancer
Jul 10, 2012 |
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Dose-escalated cetuximab tolerated in colorectal cancer
(HealthDay) -- For patients with irinotecan-refractory metastatic colorectal cancer (CRC), dose escalation of cetuximab is well tolerated and may improve response and disease control rates, but patients experience ...
Cancer
Jul 05, 2012 |
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PET imaging could lead to better care for neuroendocrine cancer
A method of molecular imaging that pinpoints hormonally active tissues in the body could change the course of treatment for a remarkable number of neuroendocrine cancer patients, say researchers at the Society of Nuclear ...
Cancer
Jun 11, 2012 |
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Life expectancy prolonged for esophageal cancer patients
For those with esophageal cancer, initial staging of the disease is of particular importance as it determines whether to opt for a curative treatment or palliative treatment. Research presented in the June issue of The Journal of ...
Cancer
Jun 04, 2012 |
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Intermittent hormone therapy for prostate cancer inferior to continuous therapy
Many men with metastatic, hormone-sensitive prostate cancer live longer on continuous androgen-deprivation therapy (also known as hormone therapy) than on intermittent therapy, according to a seventeen-year study led by SWOG, ...
Cancer
Jun 03, 2012 |
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A nurse practitioner-driven palliative care intervention improves cancer patients' quality of life
Recent studies have shown that palliative care interventions aimed at addressing patients' emotional, spiritual and social needs have a significant impact on cancer patients' quality of life and may even improve cancer patients' ...
Cancer
May 18, 2012 |
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ASCO: Dabrafenib/Trametinib active in metastatic melanoma
(HealthDay) -- For patients with V600 BRAF-mutant solid tumors, treatment with the oral BRAF inhibitor dabrafenib and the oral MEK 1/2 inhibitor trametinib is tolerated and has clinical activity in BRAF inh ...
Cancer
May 17, 2012 |
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