News tagged with molecular alterations
Study confirms everolimus can overcome trastuzumab resistance in HER-2 positive early breast cancer
A study that aimed to understand how the cancer drug everolimus helps overcome the resistance breast cancers can develop to trastuzumab has left researchers contemplating a puzzle.
Cancer
May 02, 2013 |
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Colon cancer exhibits a corresponding epigenetic pattern in mice and humans
Tumourigenesis is driven by genetic alterations and by changes in the epigenome, for instance by the addition of methyl groups to cytosine bases in the DNA. A deeper understanding of the interaction between ...
Genetics
Feb 07, 2013 |
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Genetics may explain severe flu in Chinese people
A genetic variant commonly found in Chinese people may help explain why some got seriously ill with swine flu, a discovery scientists say could help pinpoint why flu viruses hit some populations particularly ...
Diseases, Conditions, Syndromes
Jan 29, 2013 |
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Preventing prostate cancer through androgen deprivation may have harmful effects
Mice deficient in PTEN in the prostate developed stable precancers. Androgen deprivation promoted progression to invasive prostate cancer. Patients with PTEN-deficient prostate precancers may not benefit from androgen deprivation ...
Cancer
Dec 20, 2012 |
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Molecular 'portraits' of tumours match patients with trials in everyday clinical practice
Researchers in France are taking advantage of the progress in genetic and molecular profiling to analyse the make-up of individual cancer patients' tumours and, using this information, assign them to particular treatments ...
Cancer
Nov 08, 2012 |
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Molecular subtypes and genetic alterations may determine response to lung cancer therapy
Cancer therapies targeting specific molecular subtypes of the disease allow physicians to tailor treatment to a patient's individual molecular profile. But scientists are finding that in many types of cancer the molecular ...
Cancer
May 11, 2012 |
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Identifying acute myeloid leukemia gene mutations may indicate risk, best treatment
An international group of researchers, including those from Moffitt Cancer Center in Tampa, Fla., have published a paper in the March 14 issue of the New England Journal of Medicine reviewing the results of a study that a ...
Cancer
Mar 23, 2012 |
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Researchers find important 'target' playing role in tobacco-related lung cancers
Researchers at Moffitt Cancer Center in Tampa, Fla., have discovered that the immune response regulator IKBKE (serine/threonine kinase) plays two roles in tobacco-related non-small cell lung cancers. Tobacco carcinogens induce ...
Cancer
Feb 09, 2012 |
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Defects in the packaging of DNA in malignant brain tumors
Glioblastomas grow extremely aggressively into healthy brain tissue and, moreover, are highly resistant to radiation therapy and chemotherapy. Therefore, they are regarded as the most malignant type of brain tumor. Currently ...
Cancer
Jan 30, 2012 |
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Research gives new hope to those with rare vascular cancer
A specific genetic alteration has been discovered as a defining feature of epithelioid hemangioendothelioma (EHE), a rare but devastating vascular cancer. These findings have also been used to develop a new diagnostic test ...
Cancer
Aug 31, 2011 |
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Lung tumors in never-smokers show greater genomic instability than those in smokers
Lung adenocarcinomas in people who have never smoked show greater genome instability than those in smokers, supporting the theory that lung cancer in never smokers arises through different pathways, according to research ...
Cancer
Jul 05, 2011 |
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ALK rearrangement found in nearly 10 percent of patients in Lung Cancer Mutation Consortium
ALK rearrangement has been found in 9.6% of lung cancer patients tested in the Lung Cancer Mutation Consortium, and MET amplification in another 4.1%, reflecting how many patients might benefit from targeted therapies such ...
Cancer
Jul 05, 2011 |
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