G protein-coupled receptors (GPCRs) are popular drug targets, accounting for about one-third of approved drugs and many hundreds of drugs currently in development. They act as molecular switches that transduce extracellular ...
Jul 26, 2011
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Scientists report in Nature they have found a novel and unexpected molecular switch that could become a key to slowing some of the ravages of getting older as it prompts blood stem cells to age.
Oct 20, 2013
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Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich have chemically modified an anti-diabetic agent so as to make its action dependent on light. The resulting prototype compound, termed JB253, induces release of ...
Oct 14, 2014
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Tumors and certain viral infections pose a challenge to the human body which the immune system typically fails to handle. In these diseases it switches to a hypofunctional state that prevents adequate protection. However, ...
Jun 18, 2019
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An HIV drug could stop one of the early changes in skin cancer cells that leads to them becoming resistant to treatment, according to a Cancer Research UK-funded study published in Cancer Cell today.
Mar 14, 2016
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Researchers at UCLA's Jonsson Comprehensive Cancer Center have developed a way to image the spread of a particularly dangerous form of prostate cancer earlier than conventional imaging in use today, which may allow oncologists ...
Sep 22, 2011
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A protein—measuring just a few nanometers in size—acts as a molecular switch with a crucial role in determining whether we feel hungry or full. By determining of the protein's 3-D structure, researchers from Charité ...
Sep 27, 2021
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Researchers at the Peter Doherty Institute for Infection and Immunity (Doherty Institute) have identified how to increase the ability of tissue-resident memory T (TRM) cells to help fight viral infections and certain cancers.
Jul 27, 2022
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An international research team has discovered a mechanism that regulates the regeneration of the insulating layer of neurites. This insulation coating, also referred to as the myelin sheath, is crucial for rapid signal transmission ...
Nov 30, 2018
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Macrophages are part of the innate immune system and essential for brain development and function. Using a novel method, scientists from Jena University Hospital, the University of Bonn and the Memorial Sloan Kettering Cancer ...
Feb 11, 2020
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