Diseases, Conditions, Syndromes

Deconstructing the mechanics of bone marrow disease

Fibrosis is the thickening of various tissues caused by the deposition of fibrillar extracellular matrix (ECM) in tissues and organs as part of the body's wound healing response to various forms of damage. When accompanied ...

Immunology

How COVID-19 triggers massive inflammation

A study led by researchers at Boston Children's Hospital explains for the first time why COVID-19 causes severe inflammation in some people, leading to acute respiratory distress and multi-organ damage. Surprisingly, the ...

Diseases, Conditions, Syndromes

Partial bone marrow transplant 'rescues' mice with cystic fibrosis

Scientists at La Jolla Institute for Immunology (LJI) have found they can dramatically improve survival of mice with cystic fibrosis through a partial bone marrow transplant. Their new study in the Journal of Immunology shows ...

Immunology

New insights into the control of inflammation

Scientists at The Wistar Institute discovered that Early Growth Response 1 (EGR1), a protein that turns on and off specific genes during blood cell development, inhibits expression of pro-inflammatory genes in macrophages. ...

Immunology

New research may explain severe virus attacks on the lungs

In some cases, immune cells in the lungs can contribute to worsening a virus attack. In a new study, researchers at Karolinska Institutet in Sweden describe how immune cells called macrophages develop in the lungs and which ...

Diseases, Conditions, Syndromes

Role of bone marrow immune cells in COVID-19 revealed

White blood cells called monocytes released into the blood from bone marrow have abnormal features in people who have COVID-19, according to a new study by University of Manchester immunologists at the Lydia Becker Institute.

Medical research

New therapeutic options for multiple sclerosis in sight

Multiple sclerosis (MS) is known as "the disease with a thousand faces" because symptoms and progression can vary dramatically from patient to patient. But every MS patient has one thing in common: Cells of their body's own ...

Oncology & Cancer

Researchers find simpler, more effective cancer vaccine approach

Using a precursor to dendritic cells appears to be an efficient and effective way to stimulate the immune system to fight cancer tumors, according to a study in animal and cell models by researchers at the Duke Cancer Institute.

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