Health

Soviet-era pill from Bulgaria helps smokers quit

(AP) -- A pill developed in Bulgaria during the Soviet era shows promise for helping millions of smokers cheaply and safely kick the habit, the first big study of it shows.

Neuroscience

New insights into nicotine's effect on reward pathways

Northwestern scientists have discovered new mechanisms used by nicotine to manipulate the brain's reward pathway—findings which could inform the development of future anti-addiction therapies.

Addiction

Study reveals new mechanism in nicotine addiction

Part of the reason people find smoking difficult to quit is that each time they have a cigarette, feelings of craving, irritability and anxiety melt away. This component of addiction is known as negative reward and is controlled ...

Medical research

Study examines nicotine as a gateway drug

A landmark study in mice identifies a biological mechanism that could help explain how tobacco products could act as gateway drugs, increasing a person's future likelihood of abusing cocaine and perhaps other drugs as well, ...

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Nicotine

Nicotine is an alkaloid found in the nightshade family of plants (Solanaceae) which constitutes approximately 0.6–3.0% of dry weight of tobacco, with biosynthesis taking place in the roots, and accumulating in the leaves. It functions as an antiherbivore chemical with particular specificity to insects; therefore nicotine was widely used as an insecticide in the past, and currently nicotine analogs such as imidacloprid continue to be widely used.

In low concentrations (an average cigarette yields about 1 mg of absorbed nicotine), the substance acts as a stimulant in mammals and is one of the main factors responsible for the dependence-forming properties of tobacco smoking. According to the American Heart Association, "Nicotine addiction has historically been one of the hardest addictions to break." The pharmacological and behavioral characteristics that determine tobacco addiction are similar to those that determine addiction to drugs such as heroin and cocaine. Nicotine content in cigarettes has actually slowly increased over the years, and one study found that there was an average increase of 1.6% per year between the years of 1998 and 2005. This was found for all major market categories of cigarettes.

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