Researchers from the National Institutes of Natural Sciences and Nagoya City University have achieved a significant breakthrough by elucidating the structure of amyloid β (Aβ) bound to glycolipids on the surface of nerve ...
Aug 7, 2023
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21
Whether enjoyed on its own or mixed into a latte, Americano or even a martini, espresso provides an ultra-concentrated jolt of caffeine to coffee lovers. But it might do more than just wake you up. Research now published ...
Jul 19, 2023
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439
More than 70 FDA-approved cancer drugs are kinase inhibitors, which work by blocking kinases—enzymes that add phosphate groups to molecules in the cell—and preventing the chemical activity necessary for signaling and ...
Feb 13, 2023
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56
After Alzheimer's, Parkinson's is the most common neurodegenerative disease in the world. More than six million people worldwide suffer from it. In this disease, alpha-synuclein proteins form thread-like structures called ...
Nov 15, 2022
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980
A molecule known as anaplastic lymphoma kinase (ALK) is a driver of several cancers, including pediatric neuroblastoma, B-cell lymphomas, and myofibroblast tumors. But for years much about this molecule—its role in the ...
Nov 26, 2021
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115
ALK is a receptor tyrosine kinase that regulates important functions in the central nervous system. Scientists at St. Jude Children's Research Hospital have used leading-edge structural biology techniques to reveal in more ...
Nov 24, 2021
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83
Using advanced imaging technology, Mayo Clinic scientists have provided an unprecedented understanding of the BRCA1-BARD1 protein complex, which is often mutated in patients with breast or ovarian cancer. Their paper, published ...
Jul 28, 2021
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297
For the first time, researchers have pinpointed what causes normal proteins to convert to a diseased form, causing conditions like CJD and Kuru.
Mar 15, 2021
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118
A chromatin-regulating enzyme has been shown by in-depth interdisciplinary investigations to be a key driver of a common type of lung cancer. Drugs that target the enzyme could improve treatment and survival rates for this ...
Mar 15, 2021
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35
An antioxidant found in green tea may increase levels of p53, a natural anti-cancer protein, known as the "guardian of the genome" for its ability to repair DNA damage or destroy cancerous cells. Published today in Nature ...
Feb 12, 2021
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