Maintaining a regular workout routine can help you look and feel great—but did you know that exercise also helps maintain your muscles and bones? People who are unable to engage in physical activity experience weakening ...
Sep 13, 2022
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A cellular protein whose normal function appears to suppress bone formation may be a potential new target for treating osteoporosis, according to a collaborative study led by Weill Cornell Medicine and NewYork-Presbyterian ...
Sep 3, 2021
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A major health problem in older people is age-associated osteoporosis—the thinning of bone and the loss of bone density that increases the risk of fractures. Often this is accompanied by an increase in fat cells in the ...
Sep 22, 2017
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In breast cancer, there are cases of women and men whose cancer returns in their bones 20-30 years after they were treated for their primary disease and thought they were cancer-free. This phenomenon always puzzled Jefferson ...
May 13, 2019
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(Medical Xpress)—Arthritogenic alphaviruses such as Ross River virus (RRV) cause disabling joint pain. To understand what causes this pain, Suresh Mahalingam of Griffith University in Australia and his team studied how ...
A combination of two FDA-approved osteoporosis drugs with different mechanisms of action was found to increase bone density better than treatment with either drug alone in a small clinical trial. As reported in paper receiving ...
May 14, 2013
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Researchers at Mount Sinai School of Medicine have found that thyroid-stimulating hormone (TSH), a hormone produced in the anterior pituitary gland that regulates endocrine function in the thyroid gland, can promote bone ...
Sep 13, 2011
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The number of osteoporosis medications that promote bone formation are few compared to those that suppress bone resorption. A research group led by Kumamoto University scientists has discovered that the gene SIRT7 is important ...
Sep 5, 2018
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For more than a decade, Hiranmoy Das, Ph.D., has been investigating how Kruppel-like Factor 2 (KLF2), a gene that codes protein into a specific human chromosome, influences the development of bone and musculoskeletal diseases ...
Nov 20, 2020
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A research team, led by Professor Sung Ho Park in the Department of Biological Sciences at UNIST announced the results of a study on osteoblasts that damage joint bones in patients with rheumatoid arthritis.
Jan 31, 2023
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Osteoblasts (from the Greek words for "bone" and "germ" or embryonic) are mononucleate cells that are responsible for bone formation; in essence, osteoblasts are specialized fibroblasts that in addition to fibroblastic products, express bone sialoprotein and osteocalcin.
Osteoblasts produce a matrix of osteoid, which is composed mainly of Type I collagen. Osteoblasts are also responsible for mineralization of this matrix. Zinc, copper and sodium are some of the minerals required in this process. Bone is a dynamic tissue that is constantly being reshaped by osteoblasts, in charge of production of matrix and mineral, and osteoclasts, which remodel the tissue. Osteoblast cells tend to decrease with age, affecting the balance of formation and resorption in the bone tissue.
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