Diamond Blackfan Anemia (DBA) is a condition that is characterized by a failure of the bone marrow to produce red blood cells, congenital abnormalities, and a predisposition to cancer. Current treatment options, including ...
Dec 16, 2016
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Discovered in the 1970s, tumor suppressors are among the most important proteins in the body. A master regulator of growth—"the guardian of the genome"—the p53 protein monitors cell growth for errors. We rely on suppressors ...
Dec 8, 2016
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Individuals with Li-Fraumeni syndrome are at an increased risk for a number of cancers, including breast and bone cancer. Li-Fraumeni syndrome is an inherited cancer disorder caused by mutations in the tumor suppressing protein ...
Nov 21, 2016
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Could limiting food intake be a valid treatment strategy for certain types of cancers? New research in The FASEB Journal suggests "maybe." In a report appearing online in The FASEB Journal, scientists show that food restriction ...
Nov 16, 2016
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A new drug could be used to treat one of the most aggressive forms of breast cancer, a research centre based at University College Dublin and St Vincent's Hospital has discovered.
Nov 2, 2016
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Stanford researchers have found that a tumor suppressor known as p53 is stabilized by a regulatory RNA molecule called DINO. The interaction helps a cell respond to DNA damage and may play a role in cancer development and ...
Sep 26, 2016
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Microcephaly is a rare disorder that stunts brain development in utero, resulting in an abnormally small head. The Zika virus is one environmental cause of this devastating condition, but genetic defects can cause microcephaly, ...
Sep 12, 2016
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Using microsecond timescale molecular dynamics simulations, a new study published in Scientific Reports reveals p53 weak spots and sheds light on the protein instability, which is linked to its tendency to aggregate and form ...
Sep 7, 2016
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Research has shown that the growth of cancerous tumours is affected by transforming growth factor (TGFβ) in the body's cells; TGFβ both suppresses and stimulates tumour development. But it has not been understood how this ...
Aug 23, 2016
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Proteins that bind DNA or RNA are usually put in different categories, but researchers at Umeå University in Sweden and Inserm in France recently showed how the p53 protein has the capacity to bind both and how this controls ...
Aug 4, 2016
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