Genetics

What role do genome variations play in tuberculosis?

Tuberculosis is caused by Mycobacterium tuberculosis. In 2016, this was the most common causative pathogen for death by infectious diseases. Therefore, investigating the biology of infection and disease development is important ...

Diseases, Conditions, Syndromes

Genetic variation impacts pharmacokinetics of exemestane

(HealthDay)—The OATP1B1 c.521>C single nucleotide polymorphism (SNP) influences exemestane pharmacokinetics in healthy postmenopausal women, according to a study published online July 29 in the Journal of Clinical Pharmacy ...

Diseases, Conditions, Syndromes

A genetic variation may increase tuberculosis susceptibility

Researchers have shown that a single nucleotide change in a gene that affects production of hepcidin—a peptide involved in inflammation, immunity, and control of iron levels—is associated with greater susceptibility to ...

Genetics

Polymorphism in rs4343 of ACE gene linked to migraine

(HealthDay)—Angiotensin I-converting enzyme (ACE) gene rs4343 polymorphism is associated with the risk of migraine, according to a letter to the editor published online June 18 in CNS Neuroscience & Therapeutics.

Cardiology

MTHFR A1298C polymorphism not linked to MTX outcomes in RA

(HealthDay)—The methylene tetrahydrofolate reductase (MTHFR) gene A1298C polymorphism does not appear to be related to methotrexate (MTX) efficacy or toxicity in patients with rheumatoid arthritis (RA), according to a meta-analysis ...

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