Approximately two years after establishing a human cerebral organoid system to study Creutzfeldt-Jakob disease (CJD), National Institutes of Health researchers have further developed the model to screen drugs for potential ...
Mar 9, 2021
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Prion diseases are a group of rapidly progressive, fatal and infectious neurodegenerative disorders affecting both humans and animals. Bovine spongiform encephalopathy (BSE) or "mad cow" disease is one of the most famous ...
Feb 22, 2021
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One of the hallmarks of Alzheimer's disease is the formation of amyloid plaques—sticky clumps of a protein called amyloid beta—that collect between neurons in the brain. Increasingly, however, attention has turned from ...
Nov 2, 2020
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Human prion diseases include Creutzfeldt-Jakob disease (CJD) and Gerstmann-Sträussler-Scheinker disease (GSS). A new study in the open-access journal PLOS Biology reports a significant advance in the development of mouse ...
Jun 9, 2020
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Prions are a class of misfolded proteins that form aggregates called amyloid fibrils. These aggregates are the main culprit behind severe mammalian neurodegenerative diseases like Alzheimer's. What makes them so deadly is ...
Apr 7, 2020
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In the fight against neurodegenerative diseases such as frontotemporal dementia, Alzheimer's and Chronic Traumatic Encephalopathy, the tau protein is a major culprit. Found abundantly in our brain cells, tau is normally a ...
Apr 2, 2020
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A new University of Toronto study sheds light on how protein strains vary in the brains of those affected by progressive neurodegenerative diseases like Parkinson's, suggesting the need for patient-specific medicines.
Dec 4, 2019
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There are currently no effective treatments for prion diseases, a family of fatal neurodegenerative conditions caused by accumulations of misfolded copies of a naturally occurring protein. But now, there is finally an effective ...
Nov 6, 2019
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Infectious proteins called prions cause a group of related, fatal and incurable neurodegenerative disorders, including bovine spongiform encephalopathy or Mad Cow disease and Creutzfeldt-Jakob disease, both of which affect ...
Jun 11, 2019
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Two proteins central to the pathology of Alzheimer's disease act as prions—misshapen proteins that spread through tissue like an infection by forcing normal proteins to adopt the same misfolded shape—according to new ...
May 1, 2019
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