PTEN, a tumor suppressor gene mutated in approximately 20% of primary prostate cancers, and in as many as 50% of androgen deprivation-resistant prostate cancers, relies on another gene, ARID4B, to function. These findings ...
Sep 24, 2019
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77
Every year, tens thousands of men in the United States are diagnosed with low-risk prostate cancer. Most are told that they don't need treatment other than "active surveillance" to monitor their slow-growing tumors. Now, ...
Sep 16, 2019
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31
Prostate cancer often becomes lethal as it spreads to the bones, and the process behind this deadly feature could potentially be turned against it as a target for bone-targeting radiation and potential new therapies.
May 28, 2019
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80
Immunotherapy drugs known as checkpoint inhibitors have revolutionized cancer treatment: many patients with malignancies that until recently would have been considered untreatable are experiencing long-term remissions. But ...
Apr 4, 2019
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213
The development of effective anti-androgen therapies for prostate cancer is a major scientific advance. However, some men who receive these targeted treatments are more likely to develop a deadly treatment-resistant prostate ...
Feb 28, 2019
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36
For men older than about 60, an enlarged prostate means feeling the urge to make a pit stop way too often throughout the day.
Feb 4, 2019
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410
A Rutgers study has found that a specific gene in cancerous prostate tumors indicates when patients are at high-risk for the cancer to spread, suggesting that targeting this gene can help patients live longer.
Jan 17, 2019
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2364
Immunotherapy—harnessing T-cells to attack cancer cells in the body—has given hope to patients who endure round after round of treatment, including chemotherapy, to little effect. For all of its promise, however, immunotherapy ...
Oct 29, 2018
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241
Think of it as a cancer therapy zag instead of a zig. While many groups are developing cancer therapies to target proteins and pathways that are highly active in cancer cells, a team of investigators from Brigham and Women's ...
Sep 17, 2018
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85
Certain molecular drivers of cancer growth are "undruggable—it's been nearly impossible to develop chemicals that would block their action and prevent cancer growth. Many of these molecules function by passing cancer-promoting ...
Aug 9, 2018
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