A team led by Massimo Squatrito, Head of the Seve Ballesteros Foundation Brain Tumor Group at the Spanish National Cancer Research Centre (CNIO), has made important findings of how some gliomas can acquire chemoresistance. ...
Aug 4, 2020
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Just as Goldilocks sought porridge that was "just right," St. Jude Children's Research Hospital scientists reported that targeting "just right" levels of a mutant protein may offer a novel therapeutic approach to some cases ...
Jun 26, 2019
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Foetuses with a so-called new balanced chromosomal aberration have a higher risk of developing brain disorders such as autism and mental retardation than previously anticipated. The risk is 20 per cent for foetuses with these ...
May 25, 2018
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Mesothelioma is a rare and aggressive tumor that, in many cases, results from exposure to asbestos. But over the last several decades, other causes of the disease have emerged, including treatment with high-intensity therapeutic ...
Sep 14, 2017
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Large-scale changes to the structure of the genome are often seen in cancer cells. Scientists at the Babraham Institute in Cambridge, UK, have found a way to detect these changes, which could enhance cancer diagnosis and ...
Jul 4, 2017
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Immunohistochemistry (IHC) is an effective tool that can be used for identifying proto-oncogene 1 receptor tyrosine kinase (ROS1) gene rearrangements and screening patients for the administration of the targeted therapy crizotinib, ...
May 11, 2016
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A research team led by St. Jude Children's Research Hospital scientists has discovered details of how the abnormal breakage and rearrangement of chromosomes in white blood cells triggers a particularly aggressive form of ...
Feb 8, 2016
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Understanding Li–Fraumeni syndrome (LFS)—a genetic disorder that substantially increases the risk of a young person developing cancer such as the bone cancer osteosarcoma—is a first step to improving diagnosis and counseling.
Jan 27, 2016
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A blood test to regularly monitor for the presence of rearrangement of the EML4-ALK gene fusion in patients with non-small cell lung cancer (NSCLC) may help clinicians predict the outcome of treatment with crizotinib, according ...
Apr 20, 2015
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In 1982, the gene TRK was shown to cause a small percentage of colon cancers. In 2013 and 2014, next-generation sequencing of tumor samples found fusions of the TRK family of genes in at least 11 tumor types, including lung, ...
Dec 29, 2014
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