Rogue receptor opens door for rare kidney disease
Effects of a particularly devastating human kidney disease may be blunted by making a certain cellular protein receptor much less receptive, according to new research by scientists from North Carolina State University and ...
Diseases, Conditions, Syndromes
Sep 25, 2011 |
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Enzyme might be target for treating smoking, alcoholism at same time
An enzyme that appears to play a role in controlling the brain's response to nicotine and alcohol in mice might be a promising target for a drug that simultaneously would treat nicotine addiction and alcohol abuse in people, ...
Medical research
Sep 12, 2011 |
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Cardiovascular drug may offer new treatment for some difficult types of leukemia
A drug now prescribed for cardiovascular problems could become a new tool in physicians' arsenals to attack certain types of leukemia that so far have evaded effective treatments, researchers say.
Cancer
Sep 12, 2011 |
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New HIV vaccine approach targets desirable immune cells
Researchers at Duke University Medical Center, Beth Israel Deaconess Medical Center and Harvard Medical School have demonstrated an approach to HIV vaccine design that uses an altered form of HIV's outer coating or envelope ...
HIV & AIDS
Sep 01, 2011 |
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Slim down by targeting the hormone uroguanylin
The number of people who are obese and suffer one or more of its associated health problems (including type 2 diabetes) is escalating dramatically. Researchers are seeking to identify new targets for therapeutics that could ...
Medical research
Aug 25, 2011 |
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Gene found to play role in early cancer
(Medical Xpress) -- Mutations to a gene called p53 have been linked to half of all cancers, leading to tumor growth and the spread of cancerous cells. Now, a Cornell-led study identifies for the first time the mechanisms ...
Cancer
Aug 24, 2011 |
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At last, a reason why stress causes DNA damage
For years, researchers have published papers that associate chronic stress with chromosomal damage.
Medical research
Aug 21, 2011 |
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Intestinal protein may have role in ADHD, other neurological disorders
A biochemical pathway long associated with diarrhea and intestinal function may provide a new therapeutic target for treating ADHD (Attention Deficit Hyperactivity Disorder) other neuropsychiatric disorders, according to ...
Attention deficit disorders
Aug 11, 2011 |
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Dual-action protein developed better restricts blood vessel formation
(Medical Xpress) -- Cancer needs blood. In fact, some cancer medications work solely to slow or prevent cancer cells from creating new capillaries, choking off their much-needed blood and nutrient supply to halt the growth ...
Medical research
Aug 09, 2011 |
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Study finds more effective approach against ovarian cancer
In a recent issue of Cancer Research, Daniel J. Powell, Jr., PhD, a research assistant professor of Pathology and Laboratory Medicine and Obstetrics and Gynecology at the Perelman School of Medicine at the University of ...
Cancer
Aug 08, 2011 |
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Combo therapies tested to overcome drug resistance in melanoma patients
About 50 to 60 percent of patients with melanoma have a mutation in the BRAF gene that drives the growth of their cancer. Most of these patients respond well to two novel agents being studied in clinical trials that inhibit ...
Cancer
Aug 02, 2011 |
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Eliminating protein in specific brain cells blocks nicotine reward
Removing a protein from cells located in the brain's reward center blocks the anxiety-reducing and rewarding effects of nicotine, according to a new animal study in the July 27 issue of The Journal of Neuroscience. The fi ...
Neuroscience
Jul 26, 2011 |
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Common drugs initiate a molecular pas de quatre at the surface of the cell membrane
G protein-coupled receptors (GPCRs) are popular drug targets, accounting for about one-third of approved drugs and many hundreds of drugs currently in development. They act as molecular switches that transduce extracellular ...
Medical research
Jul 26, 2011 |
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Liver cancer linked to male sex hormones: HK study
Hong Kong researchers have found that men are more likely to develop liver cancer due to a type of gene which is linked to male sex hormones.
Cancer
Jul 20, 2011 |
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Key metabolic pathway implicated in intractable form of breast cancer
Using a new in vivo screening system, Whitehead Institute researchers have identified a protein in the serine biosynthesis pathway that is essential in estrogen receptor (ER)-negative breast cancer—a notoriously difficult ...
Cancer
Jul 18, 2011 |
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