A Ludwig Cancer Research study conducted in both mice and a small group of patients with advanced cancers has shown that so-called "cold" tumors that are nearly devoid of immune cells—and therefore unresponsive to immunotherapy—can ...
Sep 10, 2021
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A two-arm molecule can effectively deplete cancer-protecting cells inside tumors, allowing the immune system to fight off tumors without becoming overactive. The finding, published online in Science Translational Medicine, ...
Aug 11, 2021
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Research in mice, published today in Science Immunology by researchers at the Babraham Institute, UK and VIB-KU Leuven, Belgium, provides two solutions with potential to overcome a key clinical limitation of immune cell therapies. ...
Jul 23, 2021
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You can't make a banana split without bananas. And you can't generate stable regulatory T cells without Vitamin C or enzymes called TET proteins, it appears.
Jul 21, 2021
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In a new University of California, Irvine-led study, researchers found that a certain protein prevented regulatory T cells (Tregs) from effectively doing their job in controlling the damaging effects of inflammation in a ...
Jul 20, 2021
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When we are exposed to a pathogen, the immune system's B cells swarm to our lymph nodes, spleens, and tonsils. There, those cells mutate in germinal centers—microscopic boot camps that rush the B cells through volleys of ...
Jul 16, 2021
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While vaccines are doing a remarkable job of slowing the COVID-19 pandemic, infected people can still die from severe illness and new medications to treat them have been slow to arise. What kills these patients in the end ...
Jul 1, 2021
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Cancer immunotherapy involving drugs that inhibit CTLA-4 also activates an unwanted response that may self-limit its efficacy in fighting tumors, according to a new study led by Francesco Marangoni, Ph.D., assistant professor ...
Jun 22, 2021
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T cells—immune cells that patrol our bodies in search of trouble—have become a central focus for UC San Francisco scientists working on living cell therapies, an approach that views cells themselves as a form of medicine.
Jun 18, 2021
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Treating patients with acute respiratory failure is a constant challenge in intensive care medicine. In most cases, the underlying cause is lung inflammation triggered by a bacterial infection or—more rarely, despite being ...
Jun 2, 2021
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