Chronic inflammatory bowel disease (IBD) is becoming increasingly widespread. Until now, however, the underlying causes of the inflammation responses were unclear. Scientists at the Technical University of Munich (TUM) have ...
Feb 2, 2022
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High doses of vitamin D alleviated symptoms for patients with toxic erythema of chemotherapy (TEC) significantly faster than current treatments, according to a Northwestern Medicine study published in JAMA Dermatology.
Jan 18, 2023
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(Medical Xpress) -- Researchers from Japan recently published a paper in PLoS One describing their successful growth and transplantation of new teeth created from the stem cells of mice.
Q: Does a bone marrow transplant change your DNA?
Jan 19, 2018
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As we age our thymus shrinks and is replaced by fatty tissue, losing its essential ability to grow and develop T cells and leaving us susceptible to infections, immune disorders and cancers.
Dec 22, 2017
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During infection, HIV places copies of its genome into the DNA of cells, creating what is known as a viral reservoir. In this state, the virus effectively hides from anti-HIV drugs and the body's immune response. In most ...
Nov 15, 2021
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A clinical trial has begun which will use stem cell transplants to grow a new immune system for people with untreatable Crohn's disease—a painful and chronic intestinal disease which affects at least 115,000 people in the ...
Aug 6, 2018
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UCLA scientists have discovered a link between a protein and the ability of human blood stem cells to self-renew. In a study published today in the journal Nature, the team reports that activating the protein causes blood ...
Nov 28, 2019
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Dying retinal cells send out a rescue signal to recruit stem cells and repair eye damage, according to the findings of a new study published today in the journal Molecular Therapy. The findings open the door to restoring ...
Dec 1, 2020
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Researchers at Fred Hutchinson Cancer Research Center have identified a specific subset of adult blood stem cells that is exclusively responsible for repopulating the entire blood and immune system after a transplant.
Nov 1, 2017
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Hematopoietic stem cell transplantation (HSCT) is the transplantation of blood stem cells derived from the bone marrow (in this case known as bone marrow transplantation) or blood. Stem cell transplantation is a medical procedure in the fields of hematology and oncology, most often performed for people with diseases of the blood, bone marrow, or certain types of cancer.
With the availability of the stem cell growth factors GM-CSF and G-CSF, most hematopoietic stem cell transplantation procedures are now performed using stem cells collected from the peripheral blood, rather than from the bone marrow. Collecting peripheral blood stem cells provides a bigger graft, does not require that the donor be subjected to general anesthesia to collect the graft, results in a shorter time to engraftment, and may provide for a lower long-term relapse rate.
Hematopoietic stem cell transplantation remains a risky procedure with many possible complications; it has traditionally been reserved for patients with life-threatening diseases. While occasionally used experimentally in nonmalignant and nonhematologic indications such as severe disabling auto-immune disease and cardiovascular disease, the risk of fatal complications appears too high to gain wider acceptance.
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