For patients with acute lymphoblastic leukemia (ALL) carrying the Philadelphia chromosome and whose disease relapsed after allogeneic hematopoietic stem cell transplantation (HCT), the two-year overall survival rate has nearly ...
Jan 12, 2022
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8
In normal cells, electrical voltage patterns provide a blueprint for orderly growth. But with cancer, the opposite happens. Marked by a breakdown in the normal electrical patterns generated by the cells, they lose their specialized ...
Jan 11, 2022
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7
A new study published now in Nature Communications, led by João T. Barata from Instituto de Medicina Molecular João Lobo Antunes (iMM, Portugal), and J. Andrés Yunes from Centro Infantil Boldrini (Brazil), shows that changes ...
Dec 14, 2021
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21
The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) plays an important and previously unknown role in blocking a form of cell death called ferroptosis, according to a new study published today in Nature by researchers ...
May 12, 2021
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91
Parkinson's disease (PD) is well known as a debilitating disease that gradually worsens over time. Although the disease's progression has been largely tied to the loss of motor functions, non-motor symptoms, including the ...
Apr 5, 2021
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108
Tapping into an ancient evolutionary survival mechanism, cancer cells enter into a sluggish, slow-dividing state to survive the harsh environment created by chemotherapy or other targeted agents.
Jan 7, 2021
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484
Being traumatized can cause what are known as dissociative symptoms—such as experiencing amnesia, an out-of-body experience, feeling emotionally numb—which may help people cope. Experiencing these symptoms intensely or ...
Sep 25, 2020
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240
Targeting overactive immune cells and dampening their chronic neurotoxic effects may offer new therapeutic strategies for traumatic brain injury (TBI), according to new preclinical research in mice, which has been published ...
Feb 24, 2020
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303
Developing a therapy to combat cancer remains one of the most difficult challenges in medical research. Cancer cells use the host's own immune system to grow and spread, ultimately becoming deadly. Immune cells like macrophages, ...
Jan 30, 2020
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9
In patients with Alzheimer's disease, amyloid-beta protein fragments accumulate in the tissue and blood vessels of the brain, likely due to a faulty clearance mechanism. In experiments conducted in mice, investigators at ...
Dec 3, 2019
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