p53 is the most famous cancer gene, not least because it's involved in causing over 50% of all cancers. When a cell loses its p53 gene—when the gene becomes mutated—it unleashes many processes that lead to the uncontrolled ...
Dec 20, 2019
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A new approach to treat advanced breast cancer shuts down the growth of cells that become resistant to standard hormone therapy, according to Duke Cancer Institute animal studies.
Oct 23, 2019
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Researchers from the UCLA Jonsson Comprehensive Cancer Center and other institutions in the U.S., Canada, the United Kingdom and Singapore, have identified 1,178 biomarkers in men's genomes—the complete set of genetic material ...
Oct 8, 2019
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Colorectal cancer is a common lethal disease, and treatment decisions are increasingly influenced by which genes are mutated within each patient. Some patients with a certain gene mutation benefit from a chemotherapy drug ...
Sep 24, 2019
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Embedded at the ends of chromosomes are structures called telomeres, which in normal cells become shorter as cells divide. Progressive shortening triggers cell proliferation arrest or death. Cancer cells adopt different strategies ...
May 28, 2019
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Cutting-edge sequencing technology has revolutionized cancer diagnosis and since identified several so-called cancer driver genomic aberrations. This has led to the development of an extensive and powerful arsenal of anti-cancer ...
Mar 20, 2019
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Fatty acid metabolism is an essential process in tumor growth and proliferation. Despite attempts to block fatty acid metabolism as a therapeutic strategy to reduce tumor size and growth, the outcome has not always been positive. ...
Feb 6, 2019
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A study led by a team of Massachusetts General Hospital (MGH) investigators has analyzed, for the first time, the mechanisms underlying the use of focused ultrasound to improve the delivery of anti-cancer drugs across the ...
Aug 27, 2018
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Aggressive cancers like glioblastoma and metastatic breast cancer have in common a siren call that beckons the bone marrow to send along whatever the tumors need to survive and thrive.
Jan 23, 2018
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To the reasons that chemotherapy sometimes does not work, we can now add one more: bacteria. In a study published today in Science, researchers describe findings that certain bacteria can be found inside human pancreatic ...
Sep 15, 2017
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