News tagged with tumor suppressor gene
Related topics: cells , breast cancer , genes , cancer , cancer cells
'CYCLOPS' genes may serve as an Achilles' heel in tumor cells
BOSTON--The genomic tumult within tumor cells has provided scientists at Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard with clues to an entirely new class of genes that may serve as an Achilles' ...
Genetics
Aug 15, 2012 |
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DNA deletions promote cancer, collateral damage makes it vulnerable
Genomic deletions promote cancer by carving up or eliminating tumor-suppressor genes, but now scientists report in the journal Nature that the collateral damage they inflict on neighboring genes exposes cancer cells to vul ...
Cancer
Aug 15, 2012 |
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Rat study shows chrysotile asbestos is strong carcinogen
(HealthDay) -- Chrysotile, a commercially used type of asbestos, induces malignant mesothelioma (MM) in the rat peritoneal cavity, with pathogenesis strongly linked to iron overload, according to a study ...
Medical research
Aug 14, 2012 |
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Aurka-to-p53 signaling: A link between stem cell regulation and cancer
Researchers at Mount Sinai School of Medicine, the University of Manchester, and the MD Anderson Cancer Center have found a new role for an oncogenic signaling pathway in embryonic stem cell (ESC) self-renewal and in reprogramming ...
Medical research
Aug 03, 2012 |
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Molecular switch identified that controls key cellular process
The body has a built-in system known as autophagy, or 'self-eating,' that controls how cells live or die. Deregulation of autophagy is linked to the development of human diseases, including neural degeneration and cancer.
Medical research
Aug 01, 2012 |
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Breast cancer patients who lack RB gene respond better to neoadjuvant chemotherapy
Breast cancer patients whose tumors lacked the retinoblastoma tumor suppressor gene (RB) had an improved pathological response to neoadjuvant chemotherapy, researchers at Thomas Jefferson University Hospital and the Kimmel ...
Cancer
Jul 26, 2012 |
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New study validates activity of rare genetic variant in glioma
Researchers at Moffitt Cancer Center working with colleagues at three other institutions have validated a link between a rare genetic variant and the risk of glioma, the most common and lethal type of brain tumor. The validation ...
Genetics
Jul 02, 2012 |
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In vitro study identifies potential combination therapy for breast cancer
A study conducted at Boston University School of Medicine (BUSM) demonstrates an effective combination therapy for breast cancer cells in vitro. The findings, published in the July 2012 issue of Anticancer Research, raise ...
Cancer
Jul 02, 2012 |
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Normal gene hinders breast cancer chemotherapy
Presence of normal p53, a tumor suppressor gene, instead of a mutated version, makes breast cancer chemotherapy with doxorubicin less effective. The preclinical study led by MD Anderson scientists was published today in the ...
Cancer
Jun 11, 2012 |
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Researchers discover new combination of 2 previously approved FDA drugs to treat lung cancer
A team of researchers led by Dr. Goutham Narla at Case Western Reserve University School of Medicine in collaboration with scientists at Mount Sinai School of Medicine in New York, have discovered a previously unrecognized ...
Cancer
Jun 01, 2012 |
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The right combination: Overcoming drug resistance in cancer
Overactive epidermal growth factor receptor (EGFR) signaling has been linked to the development of cancer. Several drug therapies have been developed to treat these EGFR-associated cancers; however, many patients have developed ...
Cancer
Jun 01, 2012 |
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Clusters of cooperating tumor-suppressor genes are found in large regions deleted in common cancers
Scientists at Cold Spring Harbor Laboratory (CSHL) and Memorial Sloan-Kettering Cancer Center have amassed strong experimental evidence implying that commonly occurring large chromosomal deletions that are seen in many cancer ...
Cancer
May 07, 2012 |
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Outwitting a brainy gene
(Medical Xpress) -- The very first in the series of mutations causing colon cancer occurs in the beta-catenin gene; this gene is abnormally activated in about 90 percent of colorectal cancer patients, and in a much smaller ...
Cancer
May 01, 2012 |
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Therapy exploits 'addiction' of leukemia cells
A new study describes a therapeutic approach to halting cancer progression by exploiting a previously unrecognized "addiction" of leukemia cells to specific signaling molecules. The research, published by Cell Press online ...
Cancer
Apr 16, 2012 |
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Specific inhibition of autophagy may represent a new concept for treatment of kidney cancer
New research at the University of Cincinnati (UC) suggests that kidney cancer growth depends on autophagy, a complex process that can provide cells with nutrients from intracellular sources. Researchers say in certain circumstances ...
Cancer
Apr 16, 2012 |
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