News tagged with uncontrolled cell growth

Enzyme may be key to cancer progression in many tumors

Mutations in the KRAS gene have long been known to cause cancer, and about one third of solid tumors have KRAS mutations or mutations in the KRAS pathway. KRAS promotes cancer formation not only by driving ...

Nov 26, 2014
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Why cancer cells grow despite a lack of oxygen

Healthy cells reduce their growth when there is a lack of oxygen (hypoxia). This makes it even more surprising that hypoxia is a characteristic feature of malignant tumours. In two publications in the current ...

Nov 25, 2014
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Discovery opens up possibility of slowing cancer spread

A trawl through a library of more than 50,000 'small molecules' has identified a potential candidate to inhibit the spread of cancer cells throughout the body. Reported today in the journal Nature Communications, the mo ...

Nov 12, 2014
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Cancer cells do it the "quick-and-dirty way"

(Medical Xpress)—The hallmark of cancer is uncontrolled cell growth directed by a cell cycle engine gone into overdrive. The centrepiece of this engine is the enzyme Cdc2 kinase. While Cdc2 kinase is tightly regulated in ...

Jun 11, 2014
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Melanoma of the eye caused by two gene mutations

Researchers at the University of California, San Diego School of Medicine have identified a therapeutic target for treating the most common form of eye cancer in adults. They have also, in experiments with ...

May 29, 2014
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Light triggers death switch in cancer cells

Researchers at Cardiff University have created a peptide (a small piece of protein), linked to a light-responsive dye, capable of switching 'on' death pathways in cancer cells. The peptide remains inactive until exposed to ...

Oct 16, 2013
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Gene mutation as cause of breast and ovarian cancer

A change to the so-called TERT gene considerably increases the risk of breast and ovarian cancer. This is the result of a current, multicenter study in which the University Department of Gynaecology and the ...

May 10, 2013
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