Oncology & Cancer

New treatment approach for leukemia

The BCR/ABL gene, which does not occur among healthy people, has been shown to be a causative agent in the pathogenesis of B-cell acute lymphocytic leukemia. The gene causes white blood cells to become leukemia cells that ...

Health

Study links fracking chemicals to immune imbalance

Among predictions of a second fracking boom in the US, the first evidence that chemicals found in ground water near fracking sites can impair the immune system will be published in Toxicological Sciences on May 1. The study, ...

Oncology & Cancer

ART era has changed secondary cancers after Kaposi sarcoma

(HealthDay)—There has been a significant decline in the risk of secondary cancers after Kaposi sarcoma (KS) in the era of highly-active antiretroviral therapy (HAART), according to a study published online Aug. 24 in JAMA ...

Oncology & Cancer

Children, parents over-report leukemia treatment adherence

New research suggests that young patients with acute lymphocytic leukemia (ALL)—the most common type of pediatric cancer—and their and their parents are likely to report to their physician that they took more of their ...

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Acute lymphoblastic leukemia (ALL) is a form of leukemia, or cancer of the white blood cells characterized by excess lymphoblasts.

Malignant, immature white blood cells continuously multiply and are overproduced in the bone marrow. ALL causes damage and death by crowding out normal cells in the bone marrow, and by spreading (infiltrating) to other organs. ALL is most common in childhood with a peak incidence at 2–5 years of age, and another peak in old age. The overall cure rate in children is about 80%, and about 45%-60% of adults have long-term disease-free survival.

Acute refers to the relatively short time course of the disease (being fatal in as little as a few weeks if left untreated) to differentiate it from the very different disease of chronic lymphocytic leukemia, which has a potential time course of many years. It is interchangeably referred to as Lymphocytic or Lymphoblastic. This refers to the cells that are involved, which if they were normal would be referred to as lymphocytes but are seen in this disease in a relatively immature (also termed 'blast') state.

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