Inflammatory disorders

Medication linked to increased risk of inflammatory bowel disease

Medications that target tumor necrosis factor alpha (TNFα), a protein involved in inflammation, have revolutionized the management of certain autoimmune diseases, but paradoxically, these agents might provoke the development ...

Neuroscience

Is multiple sclerosis linked to childhood viral infections?

Although the exact causes of multiple sclerosis still remain unknown, it is assumed that the disease is triggered by a combination of genetic and environmental risk factors. But which? In a mouse model of the disease, researchers ...

Parkinson's & Movement disorders

Can gut infection trigger Parkinson's disease?

A new study by Montreal scientists published today in Nature demonstrates that a gut infection can lead to a pathology resembling Parkinson's disease (PD) in a mouse model lacking a gene linked to the human disease.

Neuroscience

Auto-immune disease: The viral route is confirmed

Why would our immune system turn against our own cells? This is the question that the combined Inserm/CNRS/ Pierre and Marie Curie University/Association Institut de Myologie have strived to answer in their "Therapies for ...

Immunology

Identifying the key genes to infection resistance

Manning the gates of our immune system are toll-like receptors (TLR)—tiny hairs that stick out of the cell membrane, recognize foreign bodies, and rally an organism's defense mechanisms. The molecular building blocks of ...

Immunology

Scientists override the body's inflammatory response

Scientists who have discovered the mechanism of a protein that suppresses inflammation in the body, say the information could potentially be used to develop new drugs to control inflammation.

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Autoimmune diseases arise from an inappropriate immune response of the body against substances and tissues normally present in the body. In other words, the immune system mistakes some part of the body as a pathogen and attacks its own cells. This may be restricted to certain organs (e.g. in autoimmune thyroiditis) or involve a particular tissue in different places (e.g. Goodpasture's disease which may affect the basement membrane in both the lung and the kidney). The treatment of autoimmune diseases is typically with immunosuppression—medication which decreases the immune response.

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