Researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg have identified a previously undocumented, organ-specific toxicity linked to CD19-targeted CAR T-cell therapy in autoimmune disease. The syndrome, termed ...
The prevalence and severity of rheumatic adverse reactions in cancer immunotherapy is significantly underestimated, due to the lack of standardized screening protocols for malignancies in patients with autoimmune disorders. ...
May 22, 2025
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A new study led by Profs. Xu Tao and He Shunmin from the Institute of Biophysics of the Chinese Academy of Sciences has revealed how human leukocyte antigen (HLA) genes, central to the immune system, influence both pathogen ...
May 21, 2025
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A new drug for pulmonary fibrosis has reduced disease progression by more than 50% over a 52-week treatment in two clinical trials. Pulmonary fibrosis is a very serious disease, with a life prognosis of 3 to 5 years after ...
May 21, 2025
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Chikungunya virus (CHIKV) is a mosquito-borne pathogen that has been identified in more than 110 countries around the world. The virus typically causes flu-like symptoms, but it can also trigger chronic, severe joint pain ...
May 20, 2025
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Many people are infected with the Epstein-Barr virus (EBV), and most are unaware of it. However, EBV can sometimes cause cancer, and this pathogen also appears to play an important role in multiple sclerosis and other autoimmune ...
May 19, 2025
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Drugs are supposed to help us get rid of disease, or at least alleviate the symptoms of them. It is therefore particularly unfortunate that—on the contrary— drugs can contribute to making us sicker. Many medications can ...
May 15, 2025
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Even after the pandemic, various new infectious diseases continue to emerge, posing ongoing viral threats that demand robust and sustained immune defenses. However, excessive immune reactions can also harm body tissues, causing ...
May 14, 2025
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Women with the autoimmune diseases rheumatoid arthritis, lupus or systemic sclerosis may have a higher rate of death related to cardiovascular disease than men with the autoimmune diseases, according to new research published ...
May 6, 2025
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Lipids are the fatty molecules that make up cellular membranes, creating a protective barrier that regulates what enters and exits the cell. Until recently, scientists believed antibodies couldn't safely target lipids without ...
May 2, 2025
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Autoimmune diseases arise from an inappropriate immune response of the body against substances and tissues normally present in the body. In other words, the immune system mistakes some part of the body as a pathogen and attacks its own cells. This may be restricted to certain organs (e.g. in autoimmune thyroiditis) or involve a particular tissue in different places (e.g. Goodpasture's disease which may affect the basement membrane in both the lung and the kidney). The treatment of autoimmune diseases is typically with immunosuppression—medication which decreases the immune response.
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