Immunology

Regulating the MS-causing properties of Th17 cells

An international study group led by researchers from Osaka University identifies a protein regulator responsible for inducing the pathogenic properties of Th17 cells, leading to multiple sclerosis and other inflammatory autoimmune ...

Health

Who's stronger? An immunological battle of the sexes

Is there anything more exciting than a battle of the sexes? In popular culture, this usually focuses on societal gender roles. But, there's another battle of the sexes, a biological war waged by the body's immune system. ...

Medical research

Human cells can also change jobs

Biology textbooks teach us that adult cell types remain fixed in the identity they have acquired upon differentiation. By inducing non-insulin-producing human pancreatic cells to modify their function to produce insulin in ...

Medical research

Antibody could increase cure rate for blood, immune disorders

An antibody-based treatment can gently and effectively eliminate diseased blood-forming stem cells in the bone marrow to prepare for the transplantation of healthy stem cells, according to a study in mice by researchers at ...

Medical research

A new mouse model may unlock the secrets of type 1 diabetes

Researchers at the University of Toledo have found a new way to replicate in lab mice the development and progression of type 1 diabetes, a breakthrough that has the potential to reshape how the chronic disease is studied.

Immunology

Masterswitch discovered in body's immune system

Scientists have discovered a critical part of the body's immune system with potentially major implications for the treatment of some of the most devastating diseases affecting humans.

Medical research

How lung tissue forms immune cell hubs in times of need

Immunology researchers at the Babraham Institute have discovered how lung tissue in mice is remodelled in response to infection with influenza in order to support an immune system response. A key result of this tissue remodelling ...

Medical research

Scientists generate functional, transplantable B cells from mice

Functional B-1 cells derived from mouse embryonic stem cells are capable of long-term engraftment and secrete natural antibodies after transplantation in mice, researchers report February 7th in the journal Stem Cell Reports. ...

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Autoimmune diseases arise from an inappropriate immune response of the body against substances and tissues normally present in the body. In other words, the immune system mistakes some part of the body as a pathogen and attacks its own cells. This may be restricted to certain organs (e.g. in autoimmune thyroiditis) or involve a particular tissue in different places (e.g. Goodpasture's disease which may affect the basement membrane in both the lung and the kidney). The treatment of autoimmune diseases is typically with immunosuppression—medication which decreases the immune response.

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