Medications

Study offers new hope for safer bleeding treatments

A new study from UNC School of Medicine researchers, published this week in Blood, provides fresh insight into how the body forms and dissolves blood clots—and may help reshape how doctors treat patients at risk of bleeding.

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A thrombus (Greek θρόμβος), or blood clot, is the final product of the blood coagulation step in hemostasis. It is achieved via the aggregation of platelets that form a platelet plug, and the activation of the humoral coagulation system (i.e. clotting factors). A thrombus is normal in cases of injury, but pathologic in instances of thrombosis.

Mural thrombi are thrombi adherent to the vessel wall. They are not occlusive and affect large vessels, such as heart and aorta. Grossly they appear grey-red with alternating light and dark lines (lines of Zahn) which represent bands of fibrin (darker) with entrapped white blood cells and red blood cells (lighter).

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