Inflammatory disorders
Cluster of new studies reveal how gut microbes work to tame intestinal inflammation
Bile acids made by the liver have long been known for their critical role in helping to absorb the food we ingest.
Mar 16, 2022
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51
Colitis
Immunology
Deciphering gut microbiome 'chatter' to combat IBD
Around 500,000 people in the UK live with Inflammatory Bowel Disease (IBD), a life-long, chronic condition characterized by sporadic bouts of gut inflammation causing debilitating symptoms. Crohn's Disease and Ulcerative ...
Mar 14, 2022
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32
Medical research
Infusion of 3D cellular structures might repair damaged intestine
Ulcerative colitis is an inflammatory bowel disease (IBD) that causes inflammation and ulcers (sores) in the digestive tract. Ulcerative colitis affects the innermost lining of the colon and rectum. It can be a debilitating ...
Feb 10, 2022
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88
Medical research
Stool samples reveal microbial enzyme driving bowel disease
Ulcerative colitis, a subtype of inflammatory bowel disease, is a chronic ailment of the colon affecting nearly one million individuals in the United States. It is thought to be linked to disruptions in the gut microbiome—the ...
Jan 28, 2022
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213
Genetics
Fighting gut infections helps prevent Crohn's disease and ulcerative colitis
A research team at the Montreal Heart Institute and Université de Montréal has shown that genes present in specific intestinal cells protect against the development of inflammatory bowel diseases. Published today in the ...
Nov 12, 2021
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136
Immunology
ATP-hydrolyzing ectoenzyme E-NTPD8 attenuates colitis
The intestinal microbial ecosystem includes diverse species of bacteria. These bacteria can produce bioactive metabolites that directly affect the host's immune system. An imbalance of microbial metabolites has been implicated ...
Sep 20, 2021
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28
Medical research
Defects in a specific cell type may cause ulcerative colitis
There are many variants of "goblet cells" in the intestines and they seem to have different functions, according to a new study from the University of Gothenburg. The study indicates that defects in goblet cells of a particular ...
Apr 19, 2021
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51
Gastroenterology
Researchers engineer novel disease model to identify potential targets for ulcerative colitis drugs
As reported in Nature Communications, researchers from Cleveland Clinic's Lerner Research Institute have developed a novel, patient-derived model of ulcerative colitis, which will help advance studies into new treatments ...
Jan 11, 2021
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30
Medical research
Discoveries reshape understanding of gut microbiome
The human gut is home to microorganisms that outnumber our cells by a factor of 10 to 1. Now, discoveries by scientists at the Oklahoma Medical Research Foundation have redefined how the so-called gut microbiome operates ...
Oct 22, 2020
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326
Immunology
Researchers identify enzyme linked to colitis
An enzyme that usually stops bacterial growth in the large intestine stimulates inflammation in some people, resulting in ulcerative colitis—a chronic digestive disease that affects more than 750,000 Americans, according ...
Aug 18, 2020
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