Oncology & Cancer

Structural insights reveal how SPOP protein contributes to cancer

SPOP is the most mutated protein in prostate cancer and plays a role in endometrial, uterine and other cancers. Despite this importance, how SPOP mutations drive cancer has been incompletely understood. Scientists at St. ...

Genetics

When and how mutant clones expand in normal endometrium

Monthly menstruation is a biological phenomenon in women of reproductive age that involves morphological and functional changes in the uterine endometrium followed by uterine lining shedding. The endometrial layer can regenerate ...

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