Medical research

First transgenic primate model created for hepatitis B research

Researchers at Oregon Health & Science University have developed the first transgenic nonhuman primate model—genetically modified to carry a human gene—for studying hepatitis B virus. The breakthrough could lead to the ...

Diseases, Conditions, Syndromes

Scientists analyze virus protein structure to advance RSV vaccines

In most people, the lung-infecting pathogens known as respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) trigger mild cold-like symptoms. But in infants and seniors, these viruses can cause severe pneumonia ...

Diseases, Conditions, Syndromes

Understanding hepatitis C

Around 2 to 3 million people live with hepatitis C in the U.S. and 40% of those people (roughly 800,000) were not even aware that they had the infection. Hepatitis C is common and completely treatable.

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Hepatitis C is an infectious disease affecting primarily the liver, caused by the hepatitis C virus (HCV). The infection is often asymptomatic, but chronic infection can lead to scarring of the liver and ultimately to cirrhosis, which is generally apparent after many years. In some cases, those with cirrhosis will go on to develop liver failure, liver cancer or life-threatening esophageal and gastric varices.

HCV is spread primarily by blood-to-blood contact associated with intravenous drug use, poorly sterilized medical equipment and transfusions. An estimated 130–170 million people worldwide are infected with hepatitis C. The existence of hepatitis C (originally "non-A non-B hepatitis") was postulated in the 1970s and proven in 1989. It is not known to cause disease in other animals.

The virus persists in the liver in about 85% of those infected. This persistent infection can be treated with medication; peginterferon and ribavirin are the current standard therapy. Overall, between 50–80% of people treated are cured. Those who develop cirrhosis or liver cancer may require a liver transplant. Hepatitis C is the leading cause of liver transplantation though the virus usually recurs after transplantation. No vaccine against hepatitis C is currently available.

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