An international group of researchers has identified an important mechanism that enables stem cells to evade immune rejection. Their research, published in Nature, sheds light on how these specialized cells create an "immune-privileged" ...
Mar 12, 2025
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Human induced pluripotent stem (hiPS) cells refer to stem cells derived from adult somatic cells like blood or skin cells. hiPS-derived cardiomyocytes (hiPC-CMs) have shown promise in treating ischemic heart disease. However, ...
Jul 10, 2024
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In a preclinical breakthrough that could transform cell therapies for incurable diseases, researchers at Sinai Health and the University of Toronto have developed a technology that may one day eliminate the need for immunosuppressive ...
Nov 29, 2023
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Cell and organ transplants can be lifesaving, but patients often encounter long waiting lists due to the shortage of suitable donors. According to donatelife.net, in 2021, 6,000 people died in the U.S. alone while waiting ...
Nov 22, 2023
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Researchers at UCSF have developed a novel, potentially life-saving approach that may prevent antibodies from triggering immune rejection of engineered therapeutic and transplant cells.
Jan 2, 2023
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Immune rejection is one of the biggest obstacles to cell therapy. To solve this problem, researchers have been investigating iPS cells that have been gene edited so that they can evade the immune system. While this concept ...
Jul 7, 2021
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UC San Francisco scientists have discovered a new way to control the immune system's 'natural killer' (NK) cells, a finding with implications for novel cell therapies and tissue implants that can evade immune rejection. The ...
Jan 8, 2021
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Approximately 30,000 organ transplants occur in the United States each year. However, between 20 and 50 percent—depending on the organ type—of the transplanted organs fail within five years, most often because the recipient's ...
Mar 20, 2017
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Despite advances in organ transplant medicine in recent decades, about half of all kidney transplant patients still lose their organ to rejection within 10 years.
Mar 15, 2016
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An international team of scientists headed by biologists at UC San Diego has discovered that an important class of stem cells known as human "induced pluripotent stem cells," or iPSCs, which are derived from an individual's ...
Aug 20, 2015
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Transplant rejection occurs when transplanted tissue is rejected by the recipient's immune system, which destroys the transplanted tissue. Transplant rejection can be lessened by determining the molecular similitude between donor and recipient and by use of immunosuppressant drugs after transplant.
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