Genetics

Two independent mechanisms are involved in tuberous sclerosis

The current idea about how tuberous sclerosis occurs places mTORC1, a protein complex that regulates cell metabolism, as the major driving force behind the disease. But according to a new study published in the Proceedings ...

Diseases, Conditions, Syndromes

Impaired blood clotting may explain higher COVID-19 risk

A new review suggests that higher-than-normal levels of an enzyme involved in blood clot prevention may be a common risk factor for developing COVID-19—a respiratory disease caused by the novel coronavirus SARS-CoV-2—in ...

Medical research

Human kidney map charts our growing immune defense

The first cell atlas of the human kidney's immune system has been created after scientists mapped nearly 70,000 individual kidney cells from early life and adults. Researchers at the Wellcome Sanger Institute, University ...

Diseases, Conditions, Syndromes

Depressive symptoms linked to rapid kidney function decline

In a study of adults with normal kidney function, those who had frequent depressive symptoms were more likely to later experience a rapid decline in kidney function. The study will appear in an upcoming issue of CJASN.

Medications

Tirzepatide improves kidney outcomes in T2DM with increased CV risk

An exploratory analysis of data from the SURPASS-4 trial has shown that adults with type 2 diabetes and increased cardiovascular risk receiving tirzepatide experience fewer renal complications, especially new onset of macroalbuminuria; ...

Other

Exploring racism's health impact in a VA renal clinic

A new study led by Penn LDI associate fellow Kevin Ahmaad Jenkins queried patients at a Veterans Administration (VA) renal clinic and found them angry, resentful, and stressed by their experiences with racism. The findings ...

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