New research from the University of Pittsburgh School of Pharmacy sheds light on the processes that lead to liver fibrosis and suggests a novel treatment approach for this common and serious condition.
Sep 25, 2024
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Formerly known as nonalcoholic steatohepatitis, metabolic dysfunction-associated steatohepatitis (MASH) is an inflammatory disease characterized by liver scarring or fibrosis that progressively impairs liver function.
Aug 22, 2024
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Liver cells have a vital metabolic inflexibility during regeneration to starve dysfunctional cells and keep damage from spreading, according to new research from Children's Medical Center Research Institute at UT Southwestern ...
Jul 26, 2024
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Statins have become the miracle medicine of modern heart care, lowering cholesterol levels and and guarding against heart attacks in millions of Americans.
Mar 5, 2024
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Researchers at Karolinska Institutet have developed a method to study liver function and disease without requiring invasive procedures. After transplanting liver cells into the eye of mice, the cornea can be used as a window ...
Feb 1, 2024
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The first successful in-patient trial of liver dialysis has been completed by researchers from UCL, the Royal Free Hospital, UCL spin-out Yaqrit and their collaborators.
May 31, 2023
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A new study from researchers at Laval University in Quebec, Canada, shows that genetically increasing omega-3 fatty acid production, without direct gut microbiota contact, improves the balance of insulin and glucagon (glucose ...
Jan 25, 2023
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A study led by Texas A&M AgriLife Research provides compelling evidence of the important role of hepatocyte adenosine kinase in the progression of nonalcoholic fatty liver disease (NAFLD). The study, "Hepatocyte Adenosine ...
Oct 5, 2022
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Sphingolipids—molecules ubiquitous throughout the human body, named after the Egyptian Sphinx for their complexity when scientists discovered them nearly 150 years ago—are not necessarily household conversation topics.
Jul 26, 2022
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The biological clock/circadian rhythm is the mechanism that ensures that a certain physiological process takes place at a specific time of the day or night. It is coordinated by the brain at a general level, but each organ ...
Sep 22, 2021
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Liver function tests (LFTs or LFs), are groups of clinical biochemistry laboratory blood assays designed to give information about the state of a patient's liver. The parameters measured include PT/INR, aPTT, albumin, billirubin (direct and indirect) and others. According to some, liver transaminases (AST/ALT (SGOT/SGPT) are not liver function tests, but are biomarkers of liver injury in a patient with some degree of intact liver function.[citation needed] Other sources include transaminases. Most liver diseases cause only mild symptoms initially, but it is vital that these diseases be detected early. Hepatic (liver) involvement in some diseases can be of crucial importance. This testing is performed by a medical technologist on a patient's serum or plasma sample obtained by phlebotomy. Some tests are associated with functionality (e.g., albumin); some with cellular integrity (e.g., transaminase) and some with conditions linked to the biliary tract (gamma-glutamyl transferase and alkaline phosphatase). Several biochemical tests are useful in the evaluation and management of patients with hepatic dysfunction. These tests can be used to (1) detect the presence of liver disease, (2) distinguish among different types of liver disorders, (3) gauge the extent of known liver damage, and (4) follow the response to treatment. Some or all of these measurements are also carried out (usually about twice a year for routine cases) on those individuals taking certain medications- anticonvulsants are a notable example- in order to ensure that the medications are not damaging the person's liver.
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