Medical research

Producing human tissue in space

On 6 March at 11:50 p.m. EST, the International Space Station resupply mission Space X CRS-20 took off from Cape Canaveral (U.S.). On board were 250 test tubes from the University of Zurich containing adult human stem cells. ...

HIV & AIDS

Immunotherapy combo achieves reservoir shrinkage in HIV model

Stimulating immune cells with two cancer immunotherapies together can shrink the size of the viral "reservoir" in SIV-infected non-human primates treated with antiviral drugs, researchers have concluded. The reservoir includes ...

Surgery

Some hospitals wary as new liver transplant rules begin

Long-delayed rules that will more broadly share scarce donated livers go into effect Tuesday, to the dismay of some hospitals in Tennessee, Kansas and other states that fear their patients may lose out.

Surgery

New tool aids patients in selecting a transplant center

A new website developed by researchers at Hennepin Healthcare Research Institute (HHRI) and the University of Minnesota (UMN) is making it easier for organ transplant candidates to choose which transplant center is right ...

Diseases, Conditions, Syndromes

New guidelines for hepatic failure in the intensive care unit

For critical care specialists, hepatic failure poses complex challenges unlike those of other critical illnesses. A new set of evidence-based recommendations for management of liver failure is presented in the March issue ...

Genetics

CRISPR 'minigene' approach stops genetic liver disease in mice

A new CRISPR gene-editing technique prevented a genetic liver disease known to be driven by hundreds of different mutations and improved clinical symptoms in mice, Penn Medicine researchers reported in new proof-of-concept ...

Diseases, Conditions, Syndromes

Nonalcoholic steatohepatitis will pose clinical, economic burden

Nonalcoholic steatohepatitis (NASH) is expected to pose a significant clinical and economic burden during the next 20 years for U.S. patients with type 2 diabetes mellitus (T2DM), according to a study published online Jan. ...

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Liver transplantation or hepatic transplantation is the replacement of a diseased liver with a healthy liver allograft. The most commonly used technique is orthotopic transplantation, in which the native liver is removed and replaced by the donor organ in the same anatomic location as the original liver. Liver transplantation nowadays is a well accepted treatment option for end-stage liver disease and acute liver failure. Typically three surgeons and one anesthesiologist are involved, with up to four supporting nurses. The surgical procedure is very demanding and ranges from 4 to 18 hours depending on outcome. Numerous anastomoses and sutures, and many disconnections and reconnections of abdominal and hepatic tissue, must be made for the transplant to succeed, requiring an eligible recipient and a well-calibrated live or cadaveric donor match. By any standard, hepatic transplantation is a major surgical procedure with an appreciable degree of risk.[citation needed]

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