Oncology & Cancer

Mutant cells colonize our tissues over our lifetime

By the time we reach middle age, more than half of the oesophagus in healthy people has been taken over by cells carrying mutations in cancer genes, scientists have uncovered. By studying normal oesophagus tissue, scientists ...

Oncology & Cancer

Study finds smoking gun for oesophageal cancer

Queensland researchers have found that sudden "chromosomal catastrophes" may trigger a third of oesophageal tumours, the fastest rising cancer in Australia.

Oncology & Cancer

Fluorescent dye pinpoints tiniest signs of oesophageal cancer

(Medical Xpress) -- A fluorescent dye that can be sprayed onto the oesophagus – the food pipe – could be used to detect oesophageal cancer earlier and spare patients unnecessary treatment, according to research ...

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Esophageal cancer (or oesophageal cancer) is malignancy of the esophagus. There are various subtypes, primarily squamous cell cancer (approx 90-95% of all esophageal cancer worldwide) and adenocarcinoma (approx. 50-80% of all esophageal cancer in the United States). Squamous cell cancer arises from the cells that line the upper part of the esophagus. Adenocarcinoma arises from glandular cells that are present at the junction of the esophagus and stomach.

Esophageal tumors usually lead to dysphagia (difficulty swallowing), pain and other symptoms, and are diagnosed with biopsy. Small and localized tumors are treated surgically with curative intent. Larger tumors tend not to be operable and hence are treated with palliative care; their growth can still be delayed with chemotherapy, radiotherapy or a combination of the two. In some cases chemo- and radiotherapy can render these larger tumors operable. Prognosis depends on the extent of the disease and other medical problems, but is fairly poor.

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