Pancreatic cancer is one of the most aggressive cancers and has one of the lowest survival rates—only 10% after five years. One of the factors contributing to its aggressiveness is its tumor microenvironment, known as the ...
Apr 15, 2025
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One of the challenges of fighting pancreatic cancer is finding ways to penetrate the organ's dense tissue to define the margins between malignant and normal tissue. A new study uses DNA origami structures to selectively deliver ...
Apr 22, 2025
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Johns Hopkins Medicine scientists say they have found a pattern of so-called epigenetic "marks" in a transition state between normal and pancreatic cancer cells in mice, and that the normal cells may keep at least a temporary ...
Apr 4, 2025
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Pancreatic cysts are fluid-filled sacs that can form in the pancreas. Some remain benign, while others have the potential to develop into pancreatic cancer. A recent study, which followed 257 patients in Japan for an average ...
Apr 18, 2025
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Van Andel Institute scientists and collaborators have developed a new method for identifying and classifying pancreatic cancer cell subtypes based on sugars found on the outside of cancer cells.
Apr 9, 2025
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Researchers at City of Hope have identified a new molecular target for treating pancreatic cancer, reports a Gastroenterology study. Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest human cancers worldwide ...
Apr 8, 2025
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In a recent study, precancerous pancreatic lesions and some pancreatic ductal adenocarcinoma (PDAC) tumors harboring KRAS mutations had higher-than-normal expression of the FGFR2 protein, and FGFR2 inactivation delayed KRAS-mutated ...
Apr 2, 2025
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Researchers at Umeå University, Sweden, have discovered a previously unknown type of connective tissue cells that surround cancer cells in pancreatic tumors. The newly discovered cells counteract tumor development and may ...
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As more people receive genetic testing after a cancer diagnosis, newer variants have been identified that increase the risk of developing cancer. A recent study led by the University of Michigan Rogel Cancer Center finds ...
Mar 27, 2025
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Pancreatic cancer refers to a malignant neoplasm originating from transformed cells arising in tissues forming the pancreas. The most common type of pancreatic cancer, accounting for 95% of these tumors, is adenocarcinoma (tumors exhibiting glandular architecture on light microscopy) arising within the exocrine component of the pancreas. A minority arise from islet cells, and are classified as neuroendocrine tumors. The symptoms that lead to diagnosis depend on the location, the size, and the tissue type of the tumor. They may include abdominal pain and jaundice (if the tumor compresses the bile duct).
Pancreatic cancer is the fourth most common cause of cancer death across the globe. Pancreatic cancer often has a poor prognosis: for all stages combined, the 1- and 5-year relative survival rates are 25% and 6%, respectively; for local disease the 5-year survival is approximately 20% while the median survival for locally advanced and for metastatic disease, which collectively represent over 80% of individuals, is about 10 and 6 months respectively.
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