Cancer drug resistance is the devastating reason that treatments fail and cancers metastasize, spreading to distant sites seeding new resistant tumors elsewhere in the body.
Pinned between the stomach and spine, the pancreas supervises both digestion and blood sugar in the body. It's also the site of an aggressive cancer called pancreatic ductal adenocarcinoma, or PDAC.
Nov 13, 2025
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Researchers have developed a new laser-based technique that targets pancreatic ductal adenocarcinoma (PDAC) while leaving healthy tissue intact. PDAC is the most common type of pancreatic cancer and the third leading cause ...
Oct 6, 2025
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Pancreatic cancer has the highest mortality rate of all major cancers, and its incidence is climbing. Because it is typically asymptomatic at early stages, pancreatic cancer is especially difficult to catch and treat in time. ...
Sep 17, 2025
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Peptidyl-arginine deiminase 2 (PAD2) enzyme converts arginine amino acid residues in histone proteins into citrulline groups and promotes tumor cell proliferation in pancreatic ductal adenocarcinoma, report researchers from ...
Aug 27, 2025
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Cancer cells and tumors do not exist in a vacuum. Far from the isolation and self-sufficiency of the fictional Wakanda, tumors develop in and alter the nearby milieu of immune cells, connective tissue, blood vessels and a ...
Jul 24, 2025
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Precancerous cells must adapt to and overcome cellular stress and inflammation in order to progress and form malignant tumors. Now, researchers at University of California San Diego School of Medicine have identified a link ...
Jul 22, 2025
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In a recent study, precancerous pancreatic lesions and some pancreatic ductal adenocarcinoma (PDAC) tumors harboring KRAS mutations had higher-than-normal expression of the FGFR2 protein, and FGFR2 inactivation delayed KRAS-mutated ...
Apr 2, 2025
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A new study by Mayo Clinic Comprehensive Cancer Center researchers found that the presence of a specific genetic mutation—KRAS circulating tumor DNA (ctDNA)—strongly indicates a higher risk of cancer spread and worse ...
Mar 19, 2025
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Researchers at the University of Virginia have discovered a new mechanism driving drug resistance in pancreatic ductal adenocarcinoma, one of the deadliest cancers. Their findings could lead to more effective treatments, ...
Nov 7, 2024
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