Obstetrics & gynaecology

Preventing the development of polycystic ovary syndrome

In a recently published review article in Nature Reviews Endocrinology, researchers conclude where the field of research is today, regarding the causes behind, and development of, polycystic ovary syndrome (PCOS). They also ...

Obstetrics & gynaecology

New theory may revolutionize treatment of endometriosis

Endometriosis, a disease found in up to 10 percent of women, has been enigmatic since it was first described. A new theory developed by researchers at Simon Fraser University suggests a previously overlooked hormone—testosterone—has ...

Genetics

Gene could help explain insulin resistance

Health researchers have known for decades that type 2 diabetes results from a phenomenon called insulin resistance, but what causes insulin resistance has remained a mystery.

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Polycystic ovary syndrome (PCOS) is one of the most common female endocrine disorders. PCOS is a complex, heterogeneous disorder of uncertain etiology, but there is strong evidence that it can to a large degree be classified as a genetic disease.

PCOS produces symptoms in approximately 5% to 10% of women of reproductive age (12–45 years old). It is thought to be one of the leading causes of female subfertility and the most frequent endocrine problem in women of reproductive age.

The principal features are anovulation, resulting in irregular menstruation, amenorrhea, ovulation-related infertility, and polycystic ovaries; excessive amounts or effects of androgenic (masculinizing) hormones, resulting in acne and hirsutism; and insulin resistance, often associated with obesity, Type 2 diabetes, and high cholesterol levels. The symptoms and severity of the syndrome vary greatly among affected women.

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