Systemic sclerosis (SSc) is a rare connective tissue disorder, with both autoimmune and vascular features. The main hallmark is tissue and vascular fibrosis that can result in clinical heterogeneity of manifestations across ...
Oct 14, 2024
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A new study from researchers with UCLA Health and collaborating organizations has found that asporin, a protein encoded by the ASPN gene, plays a protective role in pulmonary arterial hypertension (PAH).
Aug 21, 2024
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In 2023, The European Alliance of Associations for Rheumatology(EULAR) updated its recommendations for the treatment of systemic sclerosis (SSc), with many new inclusions around manifestations such as skin fibrosis and interstitial ...
Jun 14, 2024
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Pericytes, the multifunctional cells that work within the walls of capillaries, have been a subject of focus in the study of vascular development, cerebral blood flow, cancer, and neurodevelopment diseases.
Jun 12, 2024
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A drug approved to treat pulmonary arterial hypertension may be effective at managing hypertension and end-organ damage in patients with sickle cell disease, according to a new study published in Lancet Haematology.
Apr 11, 2024
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The U.S. Food and Drug Administration has approved Winrevair (sotatercept-csrk) as an injectable treatment for pulmonary arterial hypertension (PAH) in adults.
Mar 29, 2024
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University of Pittsburgh Schools of Medicine researchers uncovered a fundamental mechanism that controls the body's response to limited oxygen and regulates blood vessel disease of the lung.
Jan 10, 2024
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Physicians should be aware of a potential serious adverse effect associated with sotatercept use. A case report detailing serious and recurrent gastrointestinal bleeding is published in Annals of Internal Medicine.
Jan 1, 2024
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Infusions of potentially therapeutic cells derived from the heart are safe for people with pulmonary arterial hypertension, a form of high blood pressure that occurs in the blood vessels of the lungs and typically affects ...
Dec 13, 2023
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As an emerging concept, panvascular diseases encompass a group of cardiovascular disorders characterized mainly by atherosclerosis, involving crucial organs such as the heart, brain, kidneys, and limbs. Hypoxia-inducible ...
Aug 28, 2023
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In medicine, pulmonary hypertension (PH) is an increase in blood pressure in the pulmonary artery, pulmonary vein, or pulmonary capillaries, together known as the lung vasculature, leading to shortness of breath, dizziness, fainting, and other symptoms, all of which are exacerbated by exertion. Pulmonary hypertension can be a severe disease with a markedly decreased exercise tolerance and heart failure. It was first identified by Dr. Ernst von Romberg in 1891. According to the most recent classification, it can be one of five different types: arterial, venous, hypoxic, thromboembolic or miscellaneous.
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