Quetiapine, sold under the brand name Seroquel, is a short-acting antipsychotic drug. It's used to treat schizophrenia, bipolar I disorder and as an add-on treatment for major depression and generalised anxiety disorder in ...
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The "involuntary treatment" of unwilling psychiatric patients has long been accepted as necessary in some cases, for the sake of patients and society, though it can raise serious ethical concerns as well as legal barriers. ...
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Schizophrenia patients often experience an altered sense of self, e.g. as if someone else is controlling their actions. This impairment is described as a deficit in the "sense of agency", and while it has been well established ...
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Persons suffering from schizophrenia have a different perception of time than healthy individuals. There is far more variation in the way that a time interval is perceived by people with schizophrenic disorders than by those ...
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People with schizophrenia have trouble remembering the details of social interactions in all phases of the illness, researchers report. However, in the early stages of schizophrenia, patients can remember more about these ...
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(Medical Xpress)—Via genetic analysis, a large international team of researchers has found rare, damaging gene variants that they believe contribute to the risk of a person developing schizophrenia. In their paper published ...
Brain stimulation could be used to treat cognitive deficits frequently associated with schizophrenia, according to a new study from King's College London.
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New research has identified the culprit behind the wiring problems in the brains of people with schizophrenia. When researchers transplanted human brain cells generated from individuals diagnosed with childhood-onset schizophrenia ...
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In a new study, Norwegian researchers have documented that the cerebellum is among the most affected brain regions in schizophrenia. Compared to healthy individuals, cerebellar volume was smaller in patients with schizophrenia. ...
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UCLA researchers have found that people with schizophrenia were able to more accurately determine whether two auditory tones matched or differed, after receiving a type of electrical brain stimulation. Being able to distinguish ...
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An abundance of an amino acid called methionine, which is common in meat, cheese and beans, may provide new clues to the fetal brain development that can manifest in schizophrenia, University of California, Irvine pharmacology ...
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Labelling patients with conditions like schizophrenia or depression might become a thing of the past as doctors and scientists look beyond the symptoms to develop a new generation of psychiatric treatments.
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Research led by the University of Glasgow has made a breakthrough in developing a possible future treatment of schizophrenia and related psychiatric conditions.
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Genetic alterations of rare deletions or duplications of small DNA segments, called copy number variants (CNVs), have been known to increase risk of neurodevelopmental disorders such as schizophrenia, autism spectrum disorder, ...
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The body's acid/alkaline homeostasis, or maintenance of an adequate pH balance in tissues and organs, is important for good health. An imbalance in pH, particularly a shift toward acidity, is associated with various clinical ...
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Schizophrenia (/ˌskɪtsɵˈfrɛniə/ or /ˌskɪtsɵˈfriːniə/) is a mental disorder characterized by a breakdown of thought processes and by poor emotional responsiveness. It most commonly manifests itself as auditory hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking, and it is accompanied by significant social or occupational dysfunction. The onset of symptoms typically occurs in young adulthood, with a global lifetime prevalence of about 0.3–0.7%. Diagnosis is based on observed behavior and the patient's reported experiences.
Genetics, early environment, neurobiology, and psychological and social processes appear to be important contributory factors; some recreational and prescription drugs appear to cause or worsen symptoms. Current research is focused on the role of neurobiology, although no single isolated organic cause has been found. The many possible combinations of symptoms have triggered debate about whether the diagnosis represents a single disorder or a number of discrete syndromes. Despite the etymology of the term from the Greek roots skhizein (σχίζειν, "to split") and phrēn, phren- (φρήν, φρεν-; "mind"), schizophrenia does not imply a "split mind" and it is not the same as dissociative identity disorder—also known as "multiple personality disorder" or "split personality"—a condition with which it is often confused in public perception.
The mainstay of treatment is antipsychotic medication, which primarily suppresses dopamine (and sometimes serotonin) receptor activity. Psychotherapy and vocational and social rehabilitation are also important in treatment. In more serious cases—where there is risk to self and others—involuntary hospitalization may be necessary, although hospital stays are now shorter and less frequent than they once were.
The disorder is thought mainly to affect cognition, but it also usually contributes to chronic problems with behavior and emotion. People with schizophrenia are likely to have additional (comorbid) conditions, including major depression and anxiety disorders; the lifetime occurrence of substance abuse is almost 50%. Social problems, such as long-term unemployment, poverty and homelessness, are common. The average life expectancy of people with the disorder is 12 to 15 years less than those without, the result of increased physical health problems and a higher suicide rate (about 5%).
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