Diseases, Conditions, Syndromes

Scientists identify nearly 200 potential tuberculosis drug targets

Tuberculosis is one of the top 10 causes of death worldwide. Nearly 2 million people die every year from this infectious disease, and an estimated 2 billion people are chronically infected. The only vaccine, developed almost ...

Diseases, Conditions, Syndromes

Alcohol increases tuberculosis-related deaths in young mice

Alcohol increases the mortality of young but not old mice infected with the tuberculosis-causing bacterium Mycobacterium tuberculosis (Mtb), and this effect is mediated by the production of a protein called interferon-alpha ...

Diseases, Conditions, Syndromes

How Mycobacterium tuberculosis escapes death in macrophages

The bacteria that cause the devastating disease tuberculosis have the ability to escape destruction and grow after they are engulfed by lung macrophages, the immune cells that are supposed to destroy pathogens. Now researchers ...

Diseases, Conditions, Syndromes

Confronting TB resistance

Tuberculosis, caused by Mycobacterium tuberculosis, is a highly infectious lung disease in humans.Unfortunately, resistance to anti-tubercular medicines such as fourth-generation fluoroquinolones is on the rise. In most cases, ...

Diseases, Conditions, Syndromes

How attitudes to drug-resistant TB changed

The informal settlement of Khayelitsha in Cape Town is the latest site of a multi country trial that aims to transform the treatment for drug-resistant tuberculosis (DR-TB).

Diseases, Conditions, Syndromes

Activity of two genes able to predict active tuberculosis

The closer the contact someone has with individuals with tuberculosis, the more likely they are to become infected with the pathogen. However, only about five to ten percent of people infected with the pathogen go on to develop ...

Diseases, Conditions, Syndromes

Candidate tuberculosis vaccine in phase II/III trial

Tuberculosis remains the most deadly infectious diseases in the world. In particular, the growing number of multiresistant microbes is a cause of great concern to doctors and healthcare policymakers. At least a dozen candidate ...

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