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Endocrinology & Metabolism news
Inflammatory disorders
Metabolic modeling reveals aging microbiome produces fewer vital substances
The intestine is home to a complex ecosystem of microorganisms. This so-called gut microbiome plays an important role in health, disease, and aging. Various studies suggest that the microbiome "ages" and drives the host's ...
Apr 4, 2025
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Neuroscience
Female hormones can stimulate immune cells to make opioids that naturally suppress pain
Scientists have discovered a new mechanism that acts via an immune cell and points toward a different way of treating chronic pain. Female hormones can suppress pain by making immune cells near the spinal cord produce opioids, ...
Apr 3, 2025
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Hunger hormone found to be key in driving female binge drinking
Addiction researchers at The Florey have found a new pathway in the brain related to binge drinking in females, potentially opening a new way to help women with alcohol use disorder.
Apr 2, 2025
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Low levels of a single enzyme influence pathway to malignancy in colorectal cancer, scientists find
The transformation of healthy cells into invasive colorectal tumors is an extraordinarily complex process involving numerous molecular mechanisms, according to cancer biologists in China who have discovered that low levels ...
Protective gene found to preserve mitochondria during kidney disease progression
Research led by Children's Hospital of Fudan University in China has found that a gene called pancreatic progenitor cell differentiation and proliferation factor (PPDPF) helps protect kidney cells by supporting enzymes involved ...
Omega-3s have potential to counteract THC effects on fetal development, study finds
Previous studies show exposure to Tetrahydrocannabinol (THC)—the main psychoactive component in cannabis—while in utero can lead to lower birth weight and potential heart complications in newborn animal offspring. For ...
Apr 1, 2025
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4:3 intermittent fasting shows modestly greater weight loss than daily caloric restriction
A randomized clinical trial compared the effects of 4:3 intermittent fasting versus daily caloric restriction on weight loss when combined with comprehensive behavioral support in adults with overweight or obesity. The data ...
Apr 1, 2025
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Fecal transplants from elite athletes improve metabolic health in mice
University of Rennes researchers have discovered that transplanting gut microbiota from elite athletes into mice improves mouse insulin sensitivity and increases their muscle glycogen stores.
Does reducing cortisol really resolve health problems?
Spend a few minutes scrolling social media and you'll likely come across videos about cortisol.
Mar 31, 2025
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Chinese woman is third person to get a gene-edited pig kidney
A Chinese woman is the third person in the world living with a gene-edited pig kidney, and nearly three weeks after surgery, doctors say she's doing well.
Mar 30, 2025
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Intermittent fasting increases sex drive in male mice: An approach for low libido in humans?
Long-term fasting in 24-hour cycles increases the sex drive of male mice by lowering the concentration of the neurotransmitter serotonin in the brain. This effect is linked to a diet-induced deficiency of the precursor substance ...
Mar 28, 2025
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Oral contraceptives and smoking shown to impact steroid hormone levels in healthy adults
Steroid hormone levels in healthy adults are influenced by oral contraceptives and smoking, as well as other lifestyle choices and factors such as biological sex and age, according to new research that has just been published ...
Mar 28, 2025
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Comprehensive insights into rare triglyceride disorder provided in new study
Triglycerides are a vital source of energy, but when levels become dangerously high, they can lead to serious health complications, including pancreatitis. One such condition, chylomicronemia, is a rare but severe disorder ...
Mar 28, 2025
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Consortium advances a test to detect drug-induced liver injury
Researchers from Critical Path Institute's (C-Path) Predictive Safety Testing Consortium have proposed glutamate dehydrogenase (GLDH) as a more liver-specific biomarker for detecting liver injury, supporting clearer decision-making. ...
Mar 28, 2025
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Cyanide plays a major role in the human body, study reveals
Cyanide is a highly lethal chemical that has been used in warfare and poisonings for centuries—that was the general consensus on the naturally occurring chemical up until spring 2025. But in a global study published in ...
Mar 27, 2025
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Fueling sleep: Researchers show key metabolic link to restful nights
Scientists have long recognized the brain's need for energy, but new research from the University of Kentucky's Sanders-Brown Center on Aging has now illuminated how the brain's energy utilization significantly influences ...
Mar 27, 2025
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Atlas of brain's mitochondria reveals high cognition areas supplied with more energy
Everything the brain does—from storing memories to interpreting sights to regulating emotions—requires energy, all produced by cellular organelles called mitochondria.
Mar 26, 2025
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Calorie-free sweeteners can disrupt the brain's appetite signals, study finds
Compared to sugar, consuming sucralose—a widely used sugar substitute—increases activity in the hypothalamus, a brain region that regulates appetite and body weight, according to a new USC study.
Mar 26, 2025
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Rapid liver regeneration: New mechanism is triggered by glutamate just minutes after damage occurs
The liver is a vital organ, crucial to digestion, metabolism and the elimination of toxins. It has a unique ability, regeneration, which allows it to replace liver cells damaged by the very toxins that these cells eliminate. ...
Mar 26, 2025
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How time-restricted eating affects weight loss
Time-restricted eating is the latest craze for people looking to lose weight, but whether it works is still the calorie-burning question.
Mar 26, 2025
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Targeting hormones could reduce risk of fatty liver disease
A deeper understanding of a gene that predisposes patients to fatty liver disease may open new avenues for treatment of the condition, according to Yale research published in Cellular and Molecular Gastroenterology and Hepatology.
Mar 26, 2025
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Researchers identify neurons in brain that regulate energy levels and body temperature
Scientists at Pennington Biomedical Research Center have gained greater clarity in the brain regions and neurons that control metabolism, body temperature and energy use. Featured in the February edition of the journal Metabolism, ...
Mar 26, 2025
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Marathon runners undergo reversible reductions in myelin in the brain during a race, study reveals
A team of neurologists, neuroradiologists and biomaterials specialists affiliated with several institutions in Spain has found that marathon runners undergo a reversible reduction in myelin in the brain during a race. In ...
Most in-depth simulation of brain metabolism yet reveals new targets for future dementia treatments
A new open-source model of brain metabolism—the most complex ever generated—has shown how altering key chemicals could restore aged cells to their youthful activity and resilience.
Mar 25, 2025
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Discovery of 'cancer-cell hubs' reveals cooperative phenomena in cervical cancer
A Japanese research team has discovered a novel global cooperative phenomenon of cell interactions in cervical cancer cells. Their findings suggest that the cells are metabolically connected in a functional network. The framework ...
Mar 25, 2025
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