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Inflammatory disorders news

Diseases, Conditions, Syndromes

Treatment for chronic rhinitis yields significant clinical improvements

Neurent Medical, a company developing non-surgical interventions to treat chronic inflammatory sinonasal diseases, has released positive six-month results from the PARAGON clinical study in Ear, Nose & Throat Journal.

Inflammatory disorders

A faulty iron hormone in the skin may be the root cause of psoriasis

Scientists may have uncovered the root cause of psoriasis, a chronic and sometimes debilitating skin disease that affects 2–3% of the global population. The condition is characterized by red, scaly patches that impact the ...

Immunology

Nanobodies help decode the central mechanism of inflammation

The formation of pores by a particular protein, gasdermin D, plays a key role in inflammatory reactions. During its activation, an inhibitory part is split off. More than 30 of the remaining protein fragments then combine ...

Medications

FDA approves Bimzelx for three new indications

The U.S. Food and Drug Administration has approved Bimzelx (bimekizumab-bkzx) for the treatment of adults with active psoriatic arthritis (PsA), adults with active nonradiographic axial spondyloarthritis (nr-axSpA) with objective ...

Diseases, Conditions, Syndromes

Houston pollen count has spiked dramatically over the last decade

New data from the Houston area reveals spiking levels of ragweed, elm and cedar elm pollen as well as mold spore counts as we enter the fall season. An allergy expert at Baylor College of Medicine breaks down this information ...

Inflammatory disorders

FDA approves Tremfya for ulcerative colitis

The U.S. Food and Drug Administration has approved Johnson & Johnson's Tremfya (guselkumab) for the treatment of adults with moderately to severely active ulcerative colitis.

Inflammatory disorders

Diagnostic tool identifies puzzling inflammatory diseases in kids

RNA performs a number of biological duties, from delivering genetic information to manufacturing proteins. But RNA is also expelled from cells via cell death or active release, and can then find its way into blood plasma.

Dentistry

Altered blood markers detected in individuals with periodontitis

Individuals with periodontitis have altered concentrations of various proteins in their blood, according to a new study from Umeå University, Sweden. These findings pave the way for research into biomarkers for periodontitis ...

Inflammatory disorders

How the health of your gut microbiome can affect your skin

The skin is the largest organ of the human body. Not only does it act as the first line of defense against external stressors such as environmental toxins, pathogens and pollutants, our skin can also reveal much about our ...

Cardiology

New weapon for inflammation

Flinders University researchers have discovered a new anti-inflammatory role for well-known blood clot protein fibrinogen, which could support targeted new treatments for kidney, heart and other common diseases.

Medications

Sickle cell target could treat COVID

Scientists have found a way to lower stroke risk in sickle cell patients that opens a gateway of potential treatments for inflammation and clotting stemming from conditions such as COVID-19. For the first time, they investigated ...

Inflammatory disorders

Some inflammatory diseases linked to stroke-associated pneumonia

(HealthDay)—For patients discharged after acute ischemic stroke (AIS), the risk for stroke-associated pneumonia (SAP) is reduced for those with psoriasis or other chronic inflammatory diseases, according to a study published ...

Immunology

Exercising muscle combats chronic inflammation on its own

Biomedical engineers at Duke University have demonstrated that human muscle has an innate ability to ward off the damaging effects of chronic inflammation when exercised. The discovery was made possible through the use of ...

Immunology

New insights into the control of inflammation

Scientists at The Wistar Institute discovered that Early Growth Response 1 (EGR1), a protein that turns on and off specific genes during blood cell development, inhibits expression of pro-inflammatory genes in macrophages. ...

Health

Low fitness linked to higher psoriasis risk later in life

In a major register-based study, scientists at University of Gothenburg, Sweden, have now demonstrated a connection between inferior physical fitness in young adults and elevated risk of the autoimmune disease psoriasis. ...

Inflammatory disorders

The two sides of inflammation—the cure and the curse

One of the many wonders—and mysteries—of human biology is the complex response of the innate immune system, which is known for its swiftness in annihilating invading pathogens and capacity to mount an explosive inflammatory ...

Genetics

Scientists identify genetic risks of rare inflammatory disease

In a paper published today in the American Journal of Human Genetics, a group of international collaborators led by researchers from the University of Pittsburgh School of Medicine identified new genetic associations that ...

Immunology

Research reveals how a fungal infection activates inflammation

Scientists at St. Jude Children's Research Hospital have identified the mechanisms behind inflammasome activation driven by infection with the fungal pathogen Aspergillus fumigatus. Fungal infection, especially with A. fumigatus, ...

Obstetrics & gynaecology

Adverse pregnancy outcomes up for women with psoriasis

(HealthDay)—Pregnancies in women with psoriasis have an increased risk for adverse outcomes, including preeclampsia and stillbirth, according to a study published online Nov. 18 in the Journal of Dermatology.

Medical research

Potential new target to combat inflammatory diseases

An international team of researchers have uncovered a drug-like compound that blocks a crucial inflammatory pathway, potentially paving the way for a new treatment for a host of diseases—including COVID-19.

Medical research

Chronic inflammation causes a reduction in NAD+

NAD+ (nicotinamide adenine dinucleotide), a key metabolite central to an efficient and healthy metabolism, declines with age. This previously unexplained phenomena is associated with numerous age-related diseases and has ...