Researchers have found that melanoma cells fight anti-cancer drugs by changing their internal skeleton (cytoskeleton) - opening up a new therapeutic route for combatting skin and other cancers that develop resistance to treatment.
Jan 13, 2020
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28
For decades, a transcription factor known as STAT3 has been a major therapeutic target in the treatment of cancer. But STAT3 has largely been considered "undruggable" due to the difficulty of developing compounds to effectively ...
Nov 11, 2019
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265
One of the most common brain cancers in children, Sonic Hedgehog (SHH) medulloblastoma, also is one of the more survivable for most kids. Unfortunately, for a subset of patients the cancer resists treatment and relapses with ...
Aug 29, 2019
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102
An interdisciplinary team of UCLA scientists has found that small cell neuroendocrine cancers from a range of tissues have a common molecular signature and share drug sensitivities with blood cancers. The discoveries could ...
Jul 9, 2019
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Leukemia affects over 6,000 Canadians per year. A team of researchers used the Canadian Light Source (CLS) at the University of Saskatchewan to discover a new way to kill leukemia cancer cells. When the scientists hyperactivated ...
Jul 5, 2019
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A common genetic deficiency empowers glioblastoma to broadcast a molecular message to the wrong type of immune cell, summoning macrophages that protect and nurture the brain tumor instead of attacking it, researchers at The ...
Jun 10, 2019
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A new study out today in Cancer Cell shows that blocking specific regions of a protein called UHRF1 switches on hundreds of cancer-fighting genes, impairing colorectal cancer cells' ability to grow and spread throughout the ...
Apr 4, 2019
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60
Scientists from the German Cancer Research Center found in a recent study that only three different genetic alterations drive the early development of malignant glioblastomas. At least one of these three cancer drivers was ...
Mar 21, 2019
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128
Researchers at the San Diego branch of the Ludwig Institute for Cancer Research at University of California San Diego, with colleagues around the country, report that inhibiting activity of a specific protein in glioblastomas ...
Feb 28, 2019
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86
The development of effective anti-androgen therapies for prostate cancer is a major scientific advance. However, some men who receive these targeted treatments are more likely to develop a deadly treatment-resistant prostate ...
Feb 28, 2019
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