Journal of Biological Chemistry

Medical research

Early prevention of neuropathic pain

An unpleasant tingling in the hands and feet, numbness, fuzzy and burning sensations—these symptoms may indicate a neuropathy, a disease of the nervous system. If the pain persists for several months, it is referred to ...

Oncology & Cancer

CAR-T immunotherapy could be improved to kill solid tumors

Immunotherapy, which harnesses the power of the body's immune system to fight disease, is gaining huge traction in treating cancer. Chief among cancer immunotherapies is a treatment known as CAR-T, or chimeric antigen receptor ...

Genetics

Cause of Alzheimer's disease traced to mutation in common enzyme

Researchers from Tokyo Metropolitan University have discovered a new mechanism by which clumps of tau protein are created in the brain, killing brain cells and causing Alzheimer's disease. A specific mutation to an enzyme ...

Immunology

Gene discovery unlocks mysteries to our immunity

Australia's national science agency CSIRO has identified a new gene that plays a critical role in regulating the body's immune response to infection and disease.

Medications

New drug shows promise against toxoplasmosis

Findings from a new University of Kentucky College of Medicine study published in the Journal of Biological Chemistry May 28 may lead to a new treatment against Toxoplasma gondii, the parasite that causes toxoplasmosis.

Oncology & Cancer

Cholesterol starvation kills lymphoma cells

Scientists at Northwestern Medicine have developed a novel therapy to trick cancer cells into gobbling up what they think is their favorite food—cholesterol—which actually triggers their destruction. What appears to them ...

Medical research

New gene linked to blindness and Parkinson's disease

The retinal pigment epithelium (RPE) is a tissue, which lines the back of the eye. Aging, environmental (toxic) insults and genetic predispositions contribute to the death of RPE cells in diseases, such as age-related macular ...

Neuroscience

New insight into how brain makes memories

Every time you make a memory, somewhere in your brain a tiny filament reaches out from one neuron and forms an electrochemical connection to a neighboring neuron.

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