Transcription factors—proteins that regulate gene expression—play critical roles in cell fate decisions and are frequent targets of mutation in a variety of human cancers. Understanding how transcription factors contribute ...
Feb 5, 2021
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What if scientists knew exactly what impact the SARS-CoV-2 virus had inside our lung cells, within the first few hours of being infected? Could they use that information to find drugs that would disrupt the virus' replication ...
Jan 29, 2021
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More effective antiviral treatments could be on the way after research from The University of Texas at Austin sheds new light on the COVID-19 antiviral drug remdesivir, the only treatment of its kind currently approved in ...
Jan 28, 2021
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How do cis-regulatory genome elements regulate gene expression, what are the critical components involved, and can we therapeutically target them? By investigating how corepressors modulate enhancers and silencers during ...
Jan 27, 2021
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In the 1920s, German chemist Otto Warburg discovered that cancer cells don't metabolize sugar the same way that healthy cells usually do. Since then, scientists have tried to figure out why cancer cells use this alternative ...
Jan 15, 2021
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Damien D'Amours and his team at the Ottawa Institute of Systems Biology needed three years to discover the molecular defects associated with the LIC syndrome, a serious genetic disorder that affects young children and result ...
Dec 22, 2020
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Chemotherapy attacks all cells in our body and not just cancer cells, which is why patients undergoing the treatment often experience side effects such as physical weakness, hair loss and nausea. However, because cancer cells ...
Dec 17, 2020
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Researchers at the Francis Crick Institute have found a new way to prevent some tumors from repairing their own DNA, a function that is essential for cancer cell survival. This discovery could lead to much needed new treatments ...
Dec 16, 2020
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An LMU team has identified an enzyme that is essential for DNA repair. Loss of this factor leads to cell death when cancer cells accumulate DNA damage. Chemical inhibition of the target protein offers a possible strategy ...
Dec 4, 2020
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Utah scientists have discovered new functions of a key cellular machine that regulates gene packaging and is mutated in 20% of human cancers. The study was published in print today in the journal Molecular Cell.
Nov 19, 2020
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