Nature Reviews Drug Discovery

Medications

Scientists suggest new solution to the rare-disease problem

Thousands of rare diseases cumulatively affect millions of people across the globe, yet because each case is so rare doctors struggle to accurately diagnose and effectively treat individual patients. Every time a patient ...

Medications

How many rare diseases are there?

Some diseases are like black swans. They occur so rarely that many physicians never encounter them in their clinical practice, complicating efforts to treat them.

Medical research

Drug screens and CRISPR combine to help make better cancer drugs

A new study has created the most comprehensive analysis for understanding how cancer drugs work at a molecular level. Scientists at the Wellcome Sanger Institute, EMBL's European Bioinformatics Institute (EMBL-EBI) and AstraZeneca ...

Medications

New research predicts market share for drug makers

Lagging behind in launching new medicines means a much smaller market share for pharmaceutical companies—even if they spend just as much on advertising, according to new research from Duke University's Fuqua School of Business.

Neuroscience

How to improve multiple sclerosis therapy

Medications currently used to treat multiple sclerosis (MS) can merely reduce relapses during the initial relapsing-remitting phase. Many patients, however, develop progressive MS at a later stage, with disability becoming ...

Medications

Drug research and development more efficient than expected

Drug R&D costs have increased substantially in recent decades, while the number of new drugs has remained fairly constant, leading to concerns about the sustainability of drug R&D and question about the factors that could ...

Medications

Characteristics of international drug regulatory regimes

The regulatory requirements for the approval of new drugs vary greatly internationally in regards to the resources allocated to the authorities, the evaluation periods for approval and the fees for the pharmaceutical companies. ...

Medications

Study finds benefit to rapid drug licensing

(Medical Xpress)—Paying too much heed to possible risks when licensing a medication can lead to a pharmaceutical of great benefit to patients either not being licensed or else having its use restricted. For this reason, ...

Medications

Targeting drugs to reduce side effects

(Medical Xpress)—Consider ice cream – the base of which is frozen cream. Ingredients are then added to make different flavours. All these flavours are distinctly different but are created from the same foundation.

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