Nature Reviews Drug Discovery

Medications

How many rare diseases are there?

Some diseases are like black swans. They occur so rarely that many physicians never encounter them in their clinical practice, complicating efforts to treat them.

Neuroscience

How to improve multiple sclerosis therapy

Medications currently used to treat multiple sclerosis (MS) can merely reduce relapses during the initial relapsing-remitting phase. Many patients, however, develop progressive MS at a later stage, with disability becoming ...

Alzheimer's disease & dementia

Preventive treatment for Alzheimer's and Parkinson's disease

A diagnosis of Alzheimer's disease is devastating for those affected, as there is still no cure for this type of dementia. One hundred years after Alois Alzheimer first described it, we neither have a drug for it, nor do ...

Medications

Characteristics of international drug regulatory regimes

The regulatory requirements for the approval of new drugs vary greatly internationally in regards to the resources allocated to the authorities, the evaluation periods for approval and the fees for the pharmaceutical companies. ...

Medications

New research predicts market share for drug makers

Lagging behind in launching new medicines means a much smaller market share for pharmaceutical companies—even if they spend just as much on advertising, according to new research from Duke University's Fuqua School of Business.

Medications

Drug research and development more efficient than expected

Drug R&D costs have increased substantially in recent decades, while the number of new drugs has remained fairly constant, leading to concerns about the sustainability of drug R&D and question about the factors that could ...

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