This journal is the official publication of the International Association for the Study of Pain and publishes original research on the nature, mechanisms and treatment of pain. The journal provides a forum for the dissemination of research in the basic and clinical sciences of multidisciplinary interest.
Low back pain affects almost a third of Americans. While there is a long-standing belief that low back pain is limited to adults, research has shown it develops with increasing frequency during adolescence. With the increasing ...
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Researchers have shown that pain-induced changes in the rat brain's opioid receptor system may explain the limited effectiveness of opioid therapy in chronic pain and may play a role in the depression that often accompanies ...
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Chronic pain affects an estimated 100 million Americans, and its impact goes beyond physical discomfort.
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Nearly a quarter (23.9 per cent) of initial opioid prescriptions in Ontario had a daily dose of more than 50 milligram morphine equivalents (MME), exceeding the suggested dose threshold for opioid prescriptions outlined in ...
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A new study finds that rising placebo responses may play a part in the increasingly high failure rate for clinical trials of drugs designed to control chronic pain caused by nerve damage. Surprisingly, however, the analysis ...
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Only a quarter of publications reporting on headache clinical trials were registered in an approved clinical trial registry, a new study published today in Neurology has found.
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A study by Massachusetts General Hospital (MGH) investigators has found, for the first time in humans, that patients with chronic sciatica—back pain that shoots down the leg—have evidence of inflammation in key areas ...
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People with dementia and other forms of cognitive impairment (CI) have altered responses to pain, with many conditions associated with increased pain sensitivity, concludes a research review in Pain, the official publication ...
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Neuropathic pain is the chronic, pathological pain that continues even when the cause of pain is removed. Causes include damage to nerve cells and medicines used to treat cancer. A collaboration between research groups from ...
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In a recent paper published in the journal Pain, Saint Louis University researchers describe their success in an animal model in turning off the excruciating pain that often accompanies a colorectal cancer drug.
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