Antibodies produced within joints in rheumatoid arthritis

January 13, 2009,

Antibodies produced within the joints themselves may be responsible for joint damage in rheumatoid arthritis, according to new research published in PLoS Medicine.

Studying joint biopsies from people with rheumatoid arthritis, Costantino Pitzalis of Barts and the London School of Medicine and colleagues found that tiny structures in the joint lining mimic key functions of antibody-producing lymph nodes, and can support the production of specific antibodies that may play a role in joint destruction.

They found that these processes continued after joint tissue bearing the lymphoid structures was transplanted into mice without immune systems of their own, indicating that potentially destructive antibody production within joints can proceed independently of the body's lymph nodes.

Citation: Humby F, Bombardieri M, Manzo A, Kelly S, Blades MC, et al. (2009) Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium. PLoS Med 6(1): e1. doi:10.1371/journal.pmed.0060001
medicine.plosjournals.org/perl … journal.pmed.0060001

Source: Public Library of Science

Explore further: Small molecule could make a big difference for arthritis patients

Related Stories

Small molecule could make a big difference for arthritis patients

February 7, 2018
Will there come a time when a patient with arthritis can forgo joint replacement surgery in favor of a shot? Keck School of Medicine of USC scientist Denis Evseenko, MD, PhD, has reason to be optimistic.

Study finds bacteria in milk linked to rheumatoid arthritis

January 30, 2018
A strain of bacteria commonly found in milk and beef may be a trigger for developing rheumatoid arthritis in people who are genetically at risk, according to a new study from the University of Central Florida.

Gene delivery of drugs directly into arthritic joints is making the leap to patients

January 22, 2018
Localized gene delivery to diseased joints to achieve sustained drug production at the site of osteoarthritis or rheumatoid arthritis is gaining momentum, with clinical trials underway in the U.S. and the first arthritis ...

Fixing pain management could help us solve the opioid crisis

February 2, 2018
Australia is facing a critical public health issue of poorly managed pain. The combination of poor health outcomes, inappropriate prescribing for pain and non-prescription use of opioids has resulted in opioid-related deaths ...

Jawbone loss predates rheumatoid arthritis

December 1, 2017
Jawbone loss caused by periodontitis predates the onset of rheumatoid arthritis. This according to research from Umeå University in Sweden presented in the journal Arthritis & Rheumatology. The research also shows a causal ...

Solution for hand tremors hits the market

January 17, 2018
Technology created at a Lithuanian startup company Fidens helps to reduce uncontrollable shaking hands, which is one of the symptoms of essential tremor. The technology is effective in seven out of 10 cases, and it can also ...

Recommended for you

Past encounters with the flu shape vaccine response

February 20, 2018
New research on why the influenza vaccine was only modestly effective in recent years shows that immune history with the flu influences a person's response to the vaccine.

Building better tiny kidneys to test drugs and help people avoid dialysis

February 16, 2018
A free online kidney atlas built by USC researchers empowers stem cell scientists everywhere to generate more human-like tiny kidneys for testing new drugs and creating renal replacement therapies.

Expanding Hepatitis C testing to all adults is cost-effective and improves outcomes

February 16, 2018
According to a new study, screening all adults for hepatitis C (HCV) is a cost-effective way to improve clinical outcomes of HCV and identify more infected people compared to current recommendations. Using a simulation model, ...

Study suggests expanded range for emerging tick-borne disease

February 16, 2018
Human cases of Borrelia miyamotoi, a tick-borne infection with some similarities to Lyme disease, were discovered in the eastern United States less than a decade ago. Now new research led by the Yale School of Public Health ...

IFN-mediated immunity to influenza A virus infection influenced by RIPK3 protein

February 15, 2018
Each year, influenza kills half a million people globally with the elderly and very young most often the victims. In fact, the Centers for Disease Control and Prevention reported 37 children have died in the United States ...

Flu shot only 36 percent effective, making bad year worse (Update)

February 15, 2018
The flu vaccine is doing a poor job protecting older Americans and others against the bug that's causing most illnesses.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.