New blood-thinning drug safer than rat poison

In an article reviewed by F1000 Medicine Faculty Members Robert Ruff, Brian Olshansky and Luis Ruilope, the blood-thinner dabigatran is shown to protect against stroke, blood clotting and major bleeding as effectively as warfarin, but with fewer side effects.

The original paper, Dabigatran versus warfarin in patients with atrial , by Neal Devaraj and Stuart Connolly et al. in the , says warfarin (also commonly used in rat poison) has several drawbacks. Finding the correct dosage requires careful and laborious monitoring, and the risk of major bleeding has led to it being under-used.

With fewer side-effects and complications than warfarin, the reviewers see many potential benefits from dabigatran. According to Olshansky, it is "perhaps one of the important drug discoveries in the past decade."

Ruilope says that according to the investigators, "This oral anticoagulant prevents strokes and peripheral embolic events in patients with atrial fibrillation significantly better than that much older drug (warfarin) at different doses. It is also safer than with respect to major bleeding events."

"An immediate change of practice is not warranted but a change in standard anticoagulant therapy may be needed," Ruilope says.

More information: The full text of this article is available free for 90 days at www.f1000medicine.com/article/ … cfyz5qbtp/id/1163698

Source: Faculty of 1000: Biology and Medicine


Explore further

Study shows experimental drug cuts stroke risk

Citation: New blood-thinning drug safer than rat poison (2009, September 29) retrieved 14 June 2021 from https://medicalxpress.com/news/2009-09-blood-thinning-drug-safer-rat-poison.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments