New evidence caffeine may slow Alzheimer's disease and other dementias, restore cognitive function

May 17, 2010

Although caffeine is the most widely consumed psychoactive drug worldwide, its potential beneficial effect for maintenance of proper brain functioning has only recently begun to be adequately appreciated. Substantial evidence from epidemiological studies and fundamental research in animal models suggests that caffeine may be protective against the cognitive decline seen in dementia and Alzheimer's disease (AD). A special supplement to the Journal of Alzheimer's Disease, "Therapeutic Opportunities for Caffeine in Alzheimer's Disease and Other Neurodegenerative Diseases," sheds new light on this topic and presents key findings.

Guest editors Alexandre de Mendonça, Institute of Molecular Medicine and Faculty of Medicine, University of Lisbon, Portugal, and Rodrigo A. Cunha, Center for Neuroscience and Cell Biology of Coimbra and Faculty of Medicine, University of Coimbra, Portugal, have assembled a group of international experts to explore the effects of on the brain. The resulting collection of original studies conveys multiple perspectives on topics ranging from molecular targets of caffeine, neurophysiological modifications and adaptations, to the potential mechanisms underlying the behavioral and neuroprotective actions of caffeine in distinct brain pathologies.

"Epidemiological studies first revealed an inverse association between the chronic consumption of caffeine and the incidence of Parkinson's disease," according to Mendonça and Cunha. "This was paralleled by animal studies of Parkinson's disease showing that caffeine prevented motor deficits as well as neurodegeneration "Later a few epidemiological studies showed that the consumption of moderate amounts of caffeine was inversely associated with the associated with aging as well as the incidence of . Again, this was paralleled by animal studies showing that chronic caffeine administration prevented memory deterioration and neurodegeneration in animal models of aging and of Alzheimer's disease."

Key findings presented in "Therapeutic Opportunities for Caffeine in Alzheimer's Disease and Other ":

  • Multiple beneficial effects of caffeine to normalize brain function and prevent its degeneration
  • Caffeine's neuroprotective profile and its ability to reduce amyloid-beta production
  • Caffeine as a candidate disease-modifying agent for Alzheimer's disease
  • Positive impact of caffeine on cognition and memory performance
  • Identification of adenosine A2A receptors as the main target for neuroprotection afforded by caffeine consumption
  • Confirmation of data through valuable meta-analyses presented
  • Epidemiological studies corroborated by meta-analysis suggesting that caffeine may be protective against Parkinson's disease
  • Several methodological issues must be solved before advancing to decisive clinical trials
Mendonça and Cunha also observe that "the daily follow-up of patients with AD has taught us that improvement of daily living may be a more significant indicator of amelioration than slight improvements in objective measures of memory performance. One of the most prevalent complications of AD is depression of mood, and the recent observations that caffeine might be a mood normalizer are of particular interest."

More information: The entire issue has been made available on a no-fee basis at iospress.metapress.com/content/t13614762731/

Related Stories

Recommended for you

Study finds being in a good mood for your flu jab boosts its effectiveness

September 25, 2017
New research by a team of health experts at the University of Nottingham has found evidence that being in a positive mood on the day of your flu jab can increase its protective effect.

New tool demonstrates high cost of lack of sleep in the workplace

September 25, 2017
Sleep disorders and sleep deficiency are hidden costs that affect employers across America. Seventy percent of Americans admit that they routinely get insufficient sleep, and 30 percent of U.S. workers and 44 percent of night ...

Maternal diet could affect kids' brain reward circuitry

September 25, 2017
Researchers in France found that rats who ate a junk food diet during pregnancy had heavier pups that strongly preferred the taste of fat straight after weaning. While a balanced diet in childhood seemed to reduce the pups' ...

Exercise can make cells healthier, promoting longer life, study finds

September 22, 2017
Whether it's running, walking, cycling, swimming or rowing, it's been well-known since ancient times that doing some form of aerobic exercise is essential to good health and well-being. You can lose weight, sleep better, ...

Breathing dirty air may harm kidneys, study finds

September 21, 2017
Outdoor air pollution has long been linked to major health conditions such as heart disease, stroke, cancer, asthma and chronic obstructive pulmonary disease. A new study now adds kidney disease to the list, according to ...

Excess dietary manganese promotes staph heart infection

September 21, 2017
Too much dietary manganese—an essential trace mineral found in leafy green vegetables, fruits and nuts—promotes infection of the heart by the bacterium Staphylococcus aureus ("staph").

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.